ISOLATION OF A STREPTOCOCCUS-MUTANS STRAIN PRODUCING A NOVEL BACTERIOCIN
ISOLATION OF A STREPTOCOCCUS-MUTANS STRAIN PRODUCING A NOVEL BACTERIOCIN
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DOI：
10.1128/iai.44.1.141-144.1984
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发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
YAPHE, BI
中科院分区：
文献类型：
--
作者：
HILLMAN, JD;JOHNSON, KP;YAPHE, BI
分离到一株产生细菌素的变形链球菌，该菌株具有新的性质。它的抗生素谱包括124株变形链球菌中的123株，以及其他各种革兰氏阳性微生物。透析膜实验表明，细菌素的相对分子质量为1000。获得了细菌素产量不足或产量增加2倍的产生菌的突变株。这些菌株超级感染或先发制人地定植大鼠口腔的能力与它们产生细菌素的量有关。
A strain of S. mutans was isolated that produces a bacteriocin with novel properties. Its antibiotic spectrum includes 123 of 124 strains of S. mutans tested and a variety of other gram-positive microorganisms. Experiments with dialysis membranes indicate that the MW of the bacteriocin is < 1000. Mutants of the producer strain were obtained that are deficient in bacteriocin production or produce 2-fold elevated amounts. The ability of these strains to superinfect or preemptively colonize the oral cavities of rats correlated with the amount of bacteriocin they produced.