Catalytic Enantioselective Reaction of Allenylnitriles with Imines Using Chiral Bis(imidazoline)s Palladium(II) Pincer Complexes
Catalytic Enantioselective Reaction of Allenylnitriles with Imines Using Chiral Bis(imidazoline)s Palladium(II) Pincer Complexes
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DOI：
10.1002/anie.201702429
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发表时间：
2017-07-17
影响因子：
16.6
通讯作者：
Nakamura, Shuichi
中科院分区：
文献类型：
--
作者：
Kondo, Masaru;Omori, Masashi;Nakamura, Shuichi
首次报道了丙二烯腈与亚胺的高对映选择性反应。使用手性Phebim-Pd-II络合物与各种亚胺反应，观察到优异的产率和对映选择性。该方法为各种功能化α-亚乙烯基-β-氨基腈及其衍生物的合成提供了一条简单有效的合成路线。
The first highly enantioselective reaction of allenylnitriles with imines has been developed. Excellent yields and enantioselectivities were observed for the reaction with various imines using chiral Phebim-Pd-II complexes. This process offers a simple and efficient synthetic route for various functionalized alpha-vinylidene-beta-aminonitriles and their derivatives.