Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.
Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.
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DOI：
10.1016/j.ghir.2015.09.004
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Isaksson O
中科院分区：
文献类型：
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作者：
Yakar S;Isaksson O
生长激素(GH)及其下游介体胰岛素样生长因子-1(IGF-1)构成影响生长、代谢和器官功能的多效轴。血清GH/IGF-1水平在青春期生长过程中升高，并与骨获取高峰有关，而在衰老过程中，其水平下降，与骨丢失有关。生长激素/胰岛素样生长因子-1轴在许多生物系统中得到了广泛的研究，包括啮齿动物模型和细胞培养。这两种激素都以内分泌和自分泌/旁分泌的方式发挥作用，了解它们对骨骼获得的不同和重叠的贡献仍然是一个有争议的问题。GH和IGF-1通过与其同源受体结合而对成骨细胞发挥作用，导致一系列调节细胞分化和功能的基因被激活。这两种激素都与其他骨骼调节剂相互作用，如性类固醇、甲状腺激素和甲状旁腺激素，以促进骨骼生长和新陈代谢。在这篇综述中，我们总结了几种GH/IGF-1轴的啮齿动物模型，并描述了一些关键的实验，这些实验为GH/IGF-1轴调节骨骼生长提供了新的线索。
The growth hormone (GH) and its downstream mediator, the insulin-like growth factor-1 (IGF-1), construct a pleotropic axis affecting growth, metabolism, and organ function. Serum levels of GH/IGF-1 rise during pubertal growth and associate with peak bone acquisition, while during aging their levels decline and associate with bone loss. The GH/IGF-1 axis was extensively studied in numerous biological systems including rodent models and cell cultures. Both hormones act in an endocrine and autocrine/paracrine fashion and understanding their distinct and overlapping contributions to skeletal acquisition is still a matter of debate. GH and IGF-1 exert their effects on osteogenic cells via binding to their cognate receptor, leading to activation of an array of genes that mediate cellular differentiation and function. Both hormones interact with other skeletal regulators, such as sex-steroids, thyroid hormone, and parathyroid hormone, to facilitate skeletal growth and metabolism. In this review we summarized several rodent models of the GH/IGF-1 axis and described key experiments that shed new light on the regulation of skeletal growth by the GH/IGF-1 axis.