Prognosis of stage III or IV primary peritoneal serous papillary carcinoma
Prognosis of stage III or IV primary peritoneal serous papillary carcinoma
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DOI：
10.1016/j.ejso.2004.08.005
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发表时间：
2004-11-01
期刊：
影响因子：
3.8
通讯作者：
Castaigne, D
中科院分区：
文献类型：
--
作者：
Dubernard, G;Morice, P;Castaigne, D
目标。研究IIIC/IV期原发性腹膜浆液性乳头状癌（PSPC）患者（研究组）与上皮性腹膜浆液性乳头状癌患者（对照组）的预后。卵巢癌（EOC）（对照组）。一项回顾性病例对照研究，研究组37例患者与对照组37例患者相匹配。患者的组织学亚型（浆液性肿瘤），肿瘤分期，肿瘤分级，残留。在减积手术结束时的疾病（初始或间隔）和年龄（5岁）。最初或间隔进行减积手术。研究组手术10例，对照组手术27例，对照组手术17例，对照组手术20例。所有患者均接受以铂类为基础的化疗（联合紫杉醇）。（33）在两组中。研究组和对照组的3年总生存率分别为60%和55%（NS）。然而，3年无事件生存率（CI 95%）存在统计学差异（研究组为29%，对照组为16%：p=0.008）。腹膜疾病在PSPC患者中更为严重。新辅助化疗通常需要在PSPC中实现最佳减积手术。PSPC患者的总生存期与EOC患者相似。因此，PSPC的管理与晚期EOC的管理不应有所不同。(C)2004 Elsevier Ltd.保留所有权利。
Aims. To study the prognosis of patients with stage IIIC/IV primary peritoneal serous papillary carcinoma (PSPC) (study group) compared with that of patients with epithelial. ovarian carcinoma (EOC) (control group).Methods. A retrospective case-control study including a study group of 37 patients who were matched with a control group of 37 patients. Patients were matched for the histologic subtype (serous tumor), tumor stage, tumor grade, residual. disease at the end of debulking surgery (initial or interval) and age (5 years).Results. Debulking surgery was performed initially or at interval. surgery in respectively, 10 and 27 patients in the study group and 17 and 20 in the control group. All patients were treated with platinum-based chemotherapy (combined with paclitaxel. in 33) in both groups. The overall survival rate at 3 years in the study and control groups was, respectively, 60% versus 55% (NS). However, event-free survival rates at 3 years (Cl 95%) were statistically different (respectively, 29% in the study group versus 16% in the control group: p=0.008).Conclusions. Peritoneal disease is more bulky in patients with PSPC. Neoadjuvant chemotherapy is more often required to achieve optimal debulking surgery in PSPC. Overall survival of patients with PSPC is similar to that of their EOC counterparts. Thus, the management of PSPC should not be different from that of advanced stage EOC. (C) 2004 Elsevier Ltd. All rights reserved.