THE USE OF RACIAL CATEGORIES IN PRECISION MEDICINE RESEARCH
THE USE OF RACIAL CATEGORIES IN PRECISION MEDICINE RESEARCH
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DOI：
10.18865/ed.29.s3.651
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发表时间：
2019-12-01
影响因子：
3.2
通讯作者：
Callier, Shawneequa L.
中科院分区：
文献类型：
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作者：
Callier, Shawneequa L.
学者们已经表明，出于伦理和科学原因，促进精准医学研究的多样性和包容性非常重要。然而，对参加生物医学研究的人群进行分类的过程往往不清楚，不一致，而且缺乏合理性。精准医学研究承诺越来越细致的方法来定义研究队列和评估种族健康差异根源的多元因素。然而，由于精准医学被推广到历史上代表性不足的人群，作为阐明这些因素的工具，使用基于种族的分类对社会和医学充满了风险。本文探讨了研究人员持续使用种族的驱动因素和局限性，以及最近在精准医学研究中招募代表性不足的人群的努力。
Scholars have shown that promoting diversity and inclusion in precision medicine research is important for ethical and scientific reasons. The processes for classifying the populations that enroll in biomedical research, however, are often unclear, inconsistent, and poorly justified. Precision medicine research promises increasingly meticulous approaches to defining research cohorts and assessing the multivariate factors at the root of racial health disparities. Insofar as precision medicine is promoted to members of historically underrepresented populations as a tool for illuminating these factors, the use of race-based classifications is fraught with risks for society and medicine. This article examines the drivers and limitations of the ongoing use of race by investigators juxtaposed with recent efforts to enroll underrepresented populations in precision medicine research.