Convulsive properties of chlorinated hydrocarbon insecticides in the cat central nervous system.
Convulsive properties of chlorinated hydrocarbon insecticides in the cat central nervous system.
复制标题
氯化烃杀虫剂对猫中枢神经系统的惊厥特性。
DOI：
10.1016/0041-008x(76)90114-9
复制
发表时间：
1976
影响因子：
3.8
通讯作者：
R. Joy
中科院分区：
文献类型：
--
作者：
R. Joy
比较了氯代烃杀虫剂亚群对局部麻醉、麻痹猫的惊厥特性。狄德林、恩德林和林丹被证明是快速有效的惊厥药。它们在脑电图和诱发反应研究中产生了难以区分的变化。超同步性，有节奏的脉冲和波的爆发，以及孤立的脉冲特征是睡眠状态。癫痫发作为全身性强直阵挛型。感觉和运动皮层对感觉神经刺激的反应增强了三到五倍。奥尔德林和七氯产生类似的效果，但只有在延迟20-30分钟后，剂量增加2 - 3倍。滴滴涕的影响则更加多变。虽然它会产生惊厥行为，但脑电图的影响不同，其特征是持续的超同步。对感觉神经刺激的反应通常（但并非总是）增强。在所有剂量低于导致心血管衰竭死亡的剂量时，克坦对脑电图没有可测量的影响，也没有引起反应。这些数据表明，环氧化合物（狄氏剂和艾氏剂）和林丹对哺乳动物中枢神经系统有直接毒性，不需要代谢为活性代谢物。其次，对于环二烯，环氧化物比非环氧化物类似物更有效，更迅速地发挥作用。
The convulsive properties of subgroups of chlorinated hydrocarbon insecticides were compared in locally anesthetized, paralyzed cats. Dieldrin, endrin, and lindane proved to be rapidly acting, potent convulsants. They produced indistinguishable changes in EEG and evoked-response studies. Hypersynchrony, rhythmic bursts of spikes and waves, and isolated spikes characterized the preictal state. Seizures were of a generalized tonic-clonic type. Responses in sensory and motor cortex to sensory nerve stimulation were enhanced three- to fivefold. Aldrin and heptachlor produced similar effects but only after a delay of 20–30 min and at two to three times higher doses. DDT effects were more variable. Although it produced convulsive behavior, EEG effects differed, being characterized by sustained hypersynchrony. Responses to sensory nerve stimulation were usually, but not always, enhanced. Kelthane produced no measurable effects on EEG or evoked responses at all doses below those causing death by cardiovascular collapse. These data demonstrate that the epoxide compounds (dieldrin and aldrin) and lindane are directly toxic to the mammalian CNS and do not require metabolism to an active metabolite. Second, for the cyclodienes the epoxides are more potent and more rapid in development of effects than are the nonepoxide analogs.