Differential contribution of mesoaccumbens and mesohabenular dopamine to intracranial self-stimulation
Differential contribution of mesoaccumbens and mesohabenular dopamine to intracranial self-stimulation
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DOI：
10.1016/j.neuropharm.2013.01.005
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发表时间：
2013-07-01
影响因子：
4.7
通讯作者：
Boye, Sandra M.
中科院分区：
文献类型：
--
作者：
Duchesne, Vincent;Boye, Sandra M.
中脑多巴胺传递对颅内自我刺激的贡献是公认的。然而，虽然核的壳层和核是由两个主要的次区域组成的，但人们对它们各自对这种行为的贡献知之甚少。我们的第一个目的是研究D-安非他明注入到壳和核心的影响，以了解其相对重要性的奖励和操作性反应。我们的第二个目的是研究一组较少研究的多巴胺神经元的贡献，那些在mesohabenular通路，颅内自我刺激。在雄性Sprague道利大鼠的丘脑核壳、核芯或外侧缰中植入双侧插管，并在中脑后部植入单极刺激电极，中脑是对多巴胺传递变化敏感的大脑部位。使用曲线移动缩放，我们测量了奖励和性能增强的效果，内注射（1-20微克）和内缰（10-40微克）的D-安非他明或车辆。在伏隔核内，使用多次剂量和长时间测试使我们能够观察药物效应和输注部位之间的相互作用。我们显示，第一次，差异所需的最小剂量，以提高奖励的有效性和操作性反应，在这些增强的幅度以及在其持续时间。相反，无论剂量如何，缰核内D-苯丙胺并没有改变奖励的有效性或操作率，突出了中脑缰核和中脑缰核多巴胺通路对颅内自我刺激的不同贡献。(C)2013爱思唯尔有限公司保留所有权利。
The contribution of mesoaccumbens dopamine transmission to intracranial self-stimulation is well-established. However, although the nucleus accumbens comprises two main subregions, the shell and the core, little is known of the contribution of each to this behaviour. Our first aim was to study the effects of D-amphetamine infusions into the shell and core in order to understand their relative importance to reward and operant responding. Our second aim was to examine the contribution of a lesser studied group of dopamine neurons, those within the mesohabenular pathway, to intracranial self-stimulation. Male Sprague Dawley rats were implanted with bilateral cannulae in the nucleus accumbens shell, core or in the lateral habenula and a monopolar stimulation electrode in the posterior mesencephalon, a brain site that is sensitive to changes in dopamine transmission. Using curve-shift scaling, we measured the reward- and performance-enhancing effects of intra-accumbens (1-20 mu g) and intra-habenular (10-40 mu g) infusions of D-amphetamine or vehicle. Within the nucleus accumbens, the use of multiple doses and long test sessions allowed us to observe an interaction between drug effect and infusion site. We show, for the first time, differences in the minimal doses necessary to enhance rewarding effectiveness and operant responding, in the magnitude of these enhancements as well as in their duration. Conversely, regardless of dose, intra-habenular D-amphetamine did not alter rewarding effectiveness or operant rate, highlighting the differential contribution of mesoaccumbens and mesohabenular dopamine pathways to intracranial self-stimulation. (C) 2013 Elsevier Ltd. All rights reserved.