Complete genome sequence of Treponema pallidum, the syphilis spirochete
Complete genome sequence of Treponema pallidum, the syphilis spirochete
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DOI：
10.1126/science.281.5375.375
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发表时间：
1998-07-17
期刊：
影响因子：
56.9
通讯作者：
Venter, JC
中科院分区：
文献类型：
--
作者：
Fraser, CM;Norris, SJ;Venter, JC
梅毒螺旋体的全基因组序列被确定，并显示为1，138，006个碱基对，包含1041个预测的编码序列（开放阅读框）。DNA复制、转录、翻译和修复系统是完整的，但分解代谢和生物合成活动被最小化。可识别的转运蛋白的数量很少，没有发现phoiphoenolpyruvate：磷酸转移酶碳水化合物转运蛋白。潜在的毒力因子包括一个家族的12个潜在的膜蛋白和几个推定的溶血素。T.通过将梅毒螺旋体基因组序列与另一种致病性螺旋体莱姆病病原体伯氏疏螺旋体基因组序列进行比较，确定了独特和共同的基因，并证实了在致病性螺旋体中观察到的相当大的多样性。
The complete genome sequence of Treponema pallidum was determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. The number of identifiable transporters is small, and no phoiphoenolpyruvate: phosphotransferase carbohydrate transporters were found. Potential virulence factors include a family of 12 potential membrane proteins and several putative hemolysins. Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes.