Pediatric acute gastroenteritis associated with adenovirus 40/41 in low-income and middle-income countries.
Pediatric acute gastroenteritis associated with adenovirus 40/41 in low-income and middle-income countries.
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DOI：
10.1097/qco.0000000000000663
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发表时间：
2020-10
影响因子：
3.9
通讯作者：
Platts-Mills JA
中科院分区：
文献类型：
--
作者：
Lee B;Damon CF;Platts-Mills JA
To review the roles of enteric adenovirus types 40 and 41 and non-enteric adenoviruses in the global burden of pediatric diarrhea. Large studies using highly sensitive, type-specific molecular diagnostics have demonstrated a substantial and previously under-estimated burden of pediatric diarrheal disease due to enteric infections with adenovirus types 40/41. However, the true epidemiology of adenovirus 40/41 remains incompletely understood. Similarly, additional adenovirus types may also be implicated as agents of community-acquired pediatric gastroenteritis, but current data are too limited to elucidate their epidemiological role(s), if any. Efforts at global diarrhea control in low- and middle-income countries will require combating pediatric gastroenteritis due to enteric adenovirus infections. Future research in these settings using type-specific molecular diagnostics or strain genotyping to fully characterize the epidemiology of adenovirus 40/41 infections, identify non-40/41 adenoviruses significantly associated with gastroenteritis, and develop vaccines effective at preventing adenovirus diarrhea is warranted.
