The biogenesis and biological functions of circular RNAs and their molecular diagnostic values in cancers
The biogenesis and biological functions of circular RNAs and their molecular diagnostic values in cancers
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DOI：
10.1002/jcla.23049
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发表时间：
2020-01-01
影响因子：
2.7
通讯作者：
Sun, Weiliang
中科院分区：
文献类型：
--
作者：
Zhang, Haiyan;Shen, Yijing;Sun, Weiliang
背景除了非编码RNA（lncRNA）和microRNA（miRNAs）外，环状RNA（circular RNA）是一类具有多种功能的内源性RNA，近年来成为研究热点。CircRNA是一类广泛存在于转录组中的封闭环状RNA分子。由于缺乏游离末端，它们不容易被RNase R切割，从而避免降解。它们比线性RNA更稳定。方法通过PubMed收集数据。使用以下检索词：“环状RNA”、“circRNA”、“癌症”、”机制”、“生物发生”、“生物标志物”、”诊断“。“只包括用英文发表的文章。结果大多数circRNA表达组织/发育阶段特异性。此外，circRNA参与多种生物活性的调节。本文就circRNA的形成、分类、生物学功能及其在包括胃癌在内的常见肿瘤中的分子诊断价值作一综述（hsa_circ_002059、circ_LARP 4、hsa_circ_0000190、hsa_circ_0000096、circ-SFMBT 2和circ_PVT1），肝细胞癌（circ_104075、circRNA_100338、circ_MTO1和circZKSCAN 1），结直肠癌（hsa_circ_0136666和hsa_circ_0000523），肺癌（hsa_circ_0006427、circ_100876和circ_ABCB10），乳腺癌在一些实施方案中，所述癌症为膀胱癌（circFNDC 3B和circTFRC）和食管鳞状细胞癌（circ_100876和circ-DLG 1）。结论CircRNA不仅在肿瘤发生中起重要作用，而且可能成为新的诊断标志物。
Background In addition to non-coding RNAs (lncRNAs) and microRNAs (miRNAs), circular RNAs (circRNAs) are endogenous RNAs with various functions, which have recently become a research hotspot. CircRNAs are a kind of closed circular RNA molecule widely existing in transcriptomes. Due to lack of free ends, they are not easily cleaved by RNase R, thus avoiding degradation. They are more stable than linear RNAs. Methods Data were collected through PubMed. The following search terms were used: "circular RNA," "circRNA," "cancer," "mechanism," "biogenesis," "biomarker," "diagnosis." Only articles published in English were included. Results Most circRNAs express tissue/developmental stage specificity. Moreover, circRNAs are involved in the regulation of a variety of biological activities. In this review, we discuss the formation, classification, and biological functions of circRNAs, especially their molecular diagnostic values in common cancers, including gastric cancer (hsa_circ_002059, circ_LARP4, hsa_circ_0000190, hsa_circ_0000096, circ-SFMBT2, and circ_PVT1), hepatocellular carcinoma (circ_104075, circRNA_100338, circ_MTO1, and circZKSCAN1), colorectal cancer (hsa_circ_0136666 and hsa_circ_0000523), lung cancer (hsa_circ_0006427, circ_100876, and circ_ABCB10), breast cancer (hsa_circ_0089105, circAGFG1, and circEPSTI1), bladder cancer (circFNDC3B and circTFRC), and esophageal squamous cell carcinoma (circ_100876 and circ-DLG1). Conclusion CircRNAs not only play important roles in tumorigenesis, but also may become new diagnostic biomarkers.