Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes
Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes
复制标题
DOI：
10.1016/j.pbb.2008.10.007
复制
发表时间：
2009-03-01
影响因子：
3.6
通讯作者：
Kulkarni, Shrinivas K.
中科院分区：
文献类型：
--
作者：
Bhutani, Whit Kumar;Bishnoi, Mahendra;Kulkarni, Shrinivas K.
姜黄素是从姜黄植物根茎中提取的一种黄色色素，在亚洲各地被广泛用作食品添加剂和草药。本研究旨在研究姜黄素对慢性应激大鼠的药理、生化和神经化学的影响。姜黄素治疗(20和40 mg/kg，i.p，第21天)显著逆转了慢性不可预测的应激诱导的行为(增加不动时间)、生化(增加单胺氧化酶活性)和神经化学(脑单胺水平降低)的改变。生物利用度增强剂胡椒碱(2.5 mg/kg，i.p，21天)与姜黄素(20和40 mg/kg，i.p，21天)联合使用，可显著增强其抗不动作用。神经递质增强(5-羟色胺和多巴胺)和单胺氧化酶抑制(MAO-A)的作用与姜黄素本身的作用相比。这项研究为姜黄素及其与胡椒碱合用治疗抑郁症提供了科学依据(C)2008爱思唯尔公司。保留所有权利。
Curcumin, a yellow pigment extracted from rhizomes of the plant Curcuma longa (turmeric), has been widely used as food additive and also as a herbal medicine throughout Asia. The present study was designed to study the pharmacological, biochemical and neurochemical effects of daily administration of curcumin to rats subjected to chronic unpredictable stress. Curcumin treatment (20 and 40 mg/kg, i.p., 21 days) significantly reversed the chronic unpredictable stress-induced behavioral (increase immobility period), biochemical (increase monoamine oxidase activity) and neurochemical (depletion of brain monoamine levels) alterations. The combination of piperine (2.5 mg/kg, i.p., 21 days), a bioavailability enhancer, with curcumin (20 and 40 mg/kg, i.p., 21 days) showed significant potentiation of its anti-immobility. neurotransmitter enhancing (serotonin and dopamine) and monoamine oxidase inhibitory (MAO-A) effects as compared to curcumin effect per se. This study provided a scientific rationale for the use of curcumin and its co-administration with piperine in the treatment of depressive disorders (C) 2008 Elsevier Inc. All rights reserved.