Pulmonary function in primary pulmonary hypertension.
Pulmonary function in primary pulmonary hypertension.
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DOI：
10.1016/s0735-1097(02)02964-9
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发表时间：
2003-03
影响因子：
24
通讯作者：
Xing-guo Sun;J. E. Hansen;R. Oudiz;K. Wasserman
中科院分区：
文献类型：
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作者：
Xing-guo Sun;J. E. Hansen;R. Oudiz;K. Wasserman
目的本研究旨在确定原发性肺动脉高压（PPH）患者静息肺功能异常与疾病严重程度的相关性。尽管疾病的严重性，PPH的诊断往往被延迟，因为它是未被怀疑，并需要侵入性测量。虽然PPH往往会导致异常的静息肺功能，这些异常尚未被证明是统计学显着的PPH severity.MethodsResting肺力学和一氧化碳扩散能力DLco相关的其他措施时，在79例患者的结果符合经典的诊断标准PPH和谁没有证据的继发性肺动脉高压的证据进行了评估。这些研究结果与疾病的严重程度进行了评估，心导管，纽约心脏协会（NYHA）类，心肺运动testing.ResultsWhen PPH患者首次在我们的转诊诊所进行评估，DLco和肺容量分别减少了约四分之三和一半。DLco的减少，并在较小程度上肺容量，相关性显着减少峰值摄氧量（反映最大心输出量），峰值氧脉搏（反映最大每搏输出量），无氧阈值（反映可持续的运动能力）和较高的NYHA class. ConclusionsPPH患者通常有异常的肺力学和DLcolevels，与疾病的严重程度显着相关。这些测量可以用于评估不明原因的呼吸困难和疲劳患者。
ObjectivesThe study was done to ascertain the degree to which abnormalities in resting lung function correlate with the disease severity of patients with primary pulmonary hypertension (PPH).BackgroundPatients with PPH are often difficult to diagnose until several years after the onset of symptoms. Despite the seriousness of the disorder, the diagnosis of PPH is often delayed because it is unsuspected and requires invasive measurements. Although PPH often causes abnormalities in resting lung function, these abnormalities have not been shown to be statistically significant when correlated with other measures of PPH severity.MethodsResting lung mechanics and diffusing capacity for carbon monoxide DLcowere assessed in 79 patients whose findings conformed to the classical diagnostic criteria of PPH and who had no evidence of secondary causes of pulmonary hypertension. These findings were correlated with severity of disease as assessed by cardiac catheterization, New York Heart Association (NYHA) class, and cardiopulmonary exercise testing.ResultsWhen PPH patients were first evaluated at our referral clinic, the DLcoand lung volumes were decreased in approximately three-quarters and one-half, respectively. The decreases in DLco, and to a lesser extent lung volumes, correlated significantly with decreases in peak oxygen uptake (reflecting maximum cardiac output), peak oxygen pulse (reflecting maximum stroke volume), and anaerobic threshold (reflecting sustainable exercise capacity) and higher NYHA class.ConclusionsPatients with PPH commonly have abnormalities in lung mechanics and DLcolevels that correlate significantly with disease severity. These measurements can be useful in evaluating patients with unexplained dyspnea and fatigue.