Prediction of nocturnal plasma melatonin from morning urinary measures
Prediction of nocturnal plasma melatonin from morning urinary measures
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DOI：
10.1111/j.1600-079x.1998.tb00538.x
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发表时间：
1998-05-01
影响因子：
10.3
通讯作者：
Smith, DK
中科院分区：
文献类型：
--
作者：
Graham, C;Cook, MR;Smith, DK
越来越多的文献表明，血液中褪黑激素的水平可能对人类健康和福祉有重要影响。然而，褪黑激素在夜间合成并释放到全身循环中，并且在流行病学研究中在夜间抽取血液样本很少可行。这些是尿褪黑激素和褪黑激素的主要代谢物6-硫酸氧褪黑激素（aMT 6s）的水平准确地反映夜间血浆褪黑激素的一些证据。如果是这样的话，尿液分析可能是流行病学研究的有力工具。进行了一项基于实验室的研究，以检查78名男性的夜间血浆褪黑激素、晨尿褪黑激素和晨尿aMT 6s水平之间的关系。总夜间血浆褪黑激素与经肌酐校正的尿aMT 6和尿褪黑激素两者之间的关系是显著的。结合两个尿液测量值，耳占总血浆褪黑激素方差的72%。峰值夜间血浆褪黑激素也显着相关的尿褪黑激素和aMT 6s，尿的措施显示出良好的灵敏度和特异性，在识别夜间血浆褪黑激素水平的个体差异。这些结果支持纳入晨尿样本，以评估褪黑激素在涉及健康年轻男性的职业或住宅研究中的贡献。
A growing literature indicates that blood levels of the hormone melatonin may have important implications for human health and wellbeing. Melatonin is synthesized and released into the general circulation at night, however, and it is seldom feasible to draw blood samples at night in epidemiological studies. These is some evidence that levels of urinary melatonin and of 6-sulfatoxymelatonin (aMT6s), the major metabolite of melatonin, accurately reflect nocturnal plasma melatonin. if this is the case, urinary assays could be powerful tools for epidemiological studies. A laboratory-based study was performed to examine the relationships between nocturnal plasma melatonin, morning urinary melatonin, and morning urinary aMT6s levels in 78 men. The relationship between total nocturnal plasma melatonin and both urinary aMT6s corrected for creatinine and urinary melatonin is significant. Combining the two urinary measures accounts Ear 72% of the variance in total plasma melatonin. Peak nocturnal plasma melatonin also was significantly related to urinary melatonin and to aMT6s, The urinary measures show good sensitivity and specificity in identifying individual differences in nocturnal plasma melatonin levels. These results support the inclusion of morning urine samples to assess the contribution of the hormone melatonin in occupational or residential studies involving healthy, young men.