The Effects of Glucocorticoids on Fetal and Placental Development
The Effects of Glucocorticoids on Fetal and Placental Development
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糖皮质激素对胎儿和胎盘发育的影响
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
I. Mendilcioglu
中科院分区：
文献类型：
--
作者：
E. Korgun;A. Ozmen;G. Unek;I. Mendilcioglu
糖皮质激素 (GC) 是主要由肾上腺产生的类固醇激素，是应激反应的关键介质。虽然药理糖皮质激素过量的急性和慢性影响已得到充分认识（包括诱导高血糖、胰岛素抵抗、高脂血症、高血压和烦躁不安，并抑制免疫、炎症和认知过程），但它们在应激反应的生物学中的作用更加微妙，具有平衡的稳态作用，有助于短期生存和从挑战中恢复[1, 2]。此外，糖皮质激素在正常胎儿发育中发挥着重要作用，对于各种胎儿组织（包括肝脏、肺、肠道、骨骼肌和脂肪组织）的发育和成熟很重要，为宫外生命做好准备。糖皮质激素在妊娠后期最显着的作用是刺激肺部产生表面活性剂。这一作用对于胎儿为宫外生活做好准备至关重要，正是因为这个原因，合成糖皮质激素治疗被广泛用于早产儿，因为早产儿的肺不成熟会威胁新生儿的生存能力。尽管这些治疗极大地提高了生存率[3]，但它们并非没有副作用。
Glucocorticoids (GCs), steroid hormones produced predominantly by the adrenal gland, are key mediators of stress responses. Whilst the acute and chronic effects of pharmacological glucocorticoid excess are well-recognized (including induction of hyperglycemia, insulin resistance, hyperlipidemia, hypertension and dysphoria, with suppression of immune, inflammatory and cognitive processes), their role in the biology of the response to stress is more nuanced, with balanced homeostatic effects to facilitate short-term survival and recovery from challenge [1, 2]. In addition, glucocorticoids play an essential role in normal fetal development and are important for the development and maturation of various fetal tissues including the liver, lungs, gut, skeletal muscle and adipose tissue in preparation for extrauterine life. Glucocorticoids most notably act during late gestation to stimulate surfactant production by the lung. This action is critical to prepare the fetus for extrauterine life, and it is for this reason that synthetic glucocorticoid treatment is so widely used in preterm pregnancies where lung immaturity threatens neonatal viability. Although these treatments greatly improve survival [3], they are not without adverse effects.
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DOI：
10.1056/nejmoa0903036
发表时间：
2010-03-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Greenberger S;Boscolo E;Adini I;Mulliken JB;Bischoff J
通讯作者：
Bischoff J
检查 14 名明显盐皮质激素过多患者的基因型和表型关系。
DOI：
10.1210/jcem.83.7.4986
发表时间：
1998
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Dave-Sharma,S;Wilson,RC;Harbison,MD;Newfield,R;Azar,MR;Krozowski,ZS;Funder,JW;Shackleton,CH;Bradlow,HL;Wei,JQ;Hertecant,J;Moran,A;Neiberger,RE;Balfe,JW;Fattah,A;Daneman,D;Akkurt,HI;DeSantis,C;New,MI
通讯作者：
New,MI
地塞米松对胎儿肝脏谷氨酰胺-谷氨酸交换的影响。
DOI：
10.1152/ajpendo.2000.278.5.e839
发表时间：
2000
期刊：
American journal of physiology. Endocrinology and metabolism.
影响因子：
--
作者：
Timmerman,M;Teng,C;Wilkening,RB;Fennessey,P;Battaglia,FC;Meschia,G
通讯作者：
Meschia,G
影响因子：
4.5
作者：
Yang, Shumei;Zhang, Lubo
通讯作者：
Zhang, Lubo
影响因子：
4.8
作者：
K. Sun;L. Myatt
通讯作者：
K. Sun;L. Myatt