IMPROVED EFFICIENCY AND SELECTIVITY IN PEPTIDE-SYNTHESIS - USE OF TRIETHYLSILANE AS A CARBOCATION SCAVENGER IN DEPROTECTION OF TERT-BUTYL ESTERS AND TERT-BUTOXYCARBONYL-PROTECTED SITES
IMPROVED EFFICIENCY AND SELECTIVITY IN PEPTIDE-SYNTHESIS - USE OF TRIETHYLSILANE AS A CARBOCATION SCAVENGER IN DEPROTECTION OF TERT-BUTYL ESTERS AND TERT-BUTOXYCARBONYL-PROTECTED SITES
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DOI：
10.1016/s0040-4039(00)79116-7
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发表时间：
1992-09-08
影响因子：
1.8
通讯作者：
DOUGLAS, KT
中科院分区：
文献类型：
--
作者：
MEHTA, A;JAOUHARI, R;DOUGLAS, KT
在二氯甲烷中的三氟乙酸存在下使用三乙基硅烷作为碳阳离子清除剂导致产率增加、反应时间减少、后处理简单和在其它酸敏感性保护基团如苄氧基羰基、9-芴基甲氧基羰基、O-和S-苄基和叔丁硫基。
The use of triethylsilane as a carbocation scavenger in the presence of trifluoroacetic acid in dichloromethane leads to increased yields, decreased reaction times, simple work-up and improved selectivity for the deprotection of t-butyl ester and t-butoxycarbonyl sites in protected amino-acids and peptides in the presence of other acid-sensitive protecting groups such as the benzyloxycarbonyl, 9-fluorenylmethoxycarbonyl, O- and S-benzyl and t-butylthio groups.