Outbreak of histoplasmosis among travelers returning from El Salvador--Pennsylvania and Virginia, 2008.
Outbreak of histoplasmosis among travelers returning from El Salvador--Pennsylvania and Virginia, 2008.
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2008 年从萨尔瓦多-宾夕法尼亚州和弗吉尼亚州返回的旅行者中爆发组织胞浆菌病。
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
K. Kurkjian
中科院分区：
文献类型：
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作者：
K. Warren;A. Weltman;C. Hanks;T. LaFountain;E. Lowery;D. Woolard;C. Armstrong;A. S. Patel;K. Kurkjian
组织胞浆菌病是一种由荚膜组织胞浆菌感染引起的真菌病。组织胞浆菌病可以从被鸟类或蝙蝠粪便污染的土壤中获得，在世界各地都有发生，是美国最常见的肺部和全身性真菌病之一。然而，在从组织胞浆菌病流行地区返回的国际旅行者中，组织胞浆菌病很少见，占该群体诊断的所有疾病的<0.5%。 2008 年 2 月至 3 月期间，宾夕法尼亚州和弗吉尼亚州卫生部门对分别前往萨尔瓦多翻修一座教堂的三个传教团进行了一系列呼吸道疾病调查。本报告总结了调查结果。在三个任务组的 33 名旅行者中，有 20 名 (61%) 符合组织胞浆菌病病例定义。据报告在户外清扫和清洁（相对风险 [RR] = 2.1，95% 置信区间 [CI] = 1.3-3.6）、挖掘（RR = 2.6，CI = 1.1-6.1）或在鸟类或蝙蝠栖息地工作（RR = 1.8，CI = 1.3-2.4）的人患病风险较高。研究结果强调，旅行者和参与建筑活动的人员在组织胞浆菌病流行的地区工作时需要使用个人防护装备并减少粉尘的产生。临床医生应将组织胞浆菌病视为从组织胞浆菌病流行地区返回的旅行者引起急性呼吸道疾病或流感样疾病的可能原因。
Histoplasmosis is a fungal disease caused by infection with Histoplasma capsulatum. Histoplasmosis, which can be acquired from soil contaminated with bird or bat droppings, occurs worldwide and is one of the most common pulmonary and systemic mycoses in the United States. However, among international travelers returning from areas in which histoplasmosis is endemic, histoplasmosis is rare, accounting for <0.5% of all diseases diagnosed in this group. During February-March 2008, the Pennsylvania and Virginia departments of health investigated a cluster of respiratory illness among three mission groups that had traveled separately to El Salvador to renovate a church. This report summarizes the results of the investigation. Of 33 travelers in the three mission groups for whom information was available, 20 (61%) met the case definition for histoplasmosis. Persons who reported sweeping and cleaning outdoors (relative risk [RR] = 2.1, 95% confidence interval [CI] = 1.3-3.6), digging (RR = 2.6, CI = 1.1-6.1), or working in a bird or bat roosting area (RR = 1.8, CI = 1.3-2.4) had a greater risk for illness. The findings emphasize the need for travelers and persons involved in construction activities to use personal protective equipment and decrease dust-generation when working in areas where histoplasmosis is endemic. Clinicians should consider histoplasmosis as a possible cause of acute respiratory or influenza-like illness in travelers returning from areas in which histoplasmosis is endemic.