Antilymphocyte antibodies and systemic lupus erythematosus.
Antilymphocyte antibodies and systemic lupus erythematosus.
复制标题
抗淋巴细胞抗体和系统性红斑狼疮。
DOI：
10.1002/art.1780300215
复制
发表时间：
1987
影响因子：
--
通讯作者：
Schlossman,SF
中科院分区：
文献类型：
--
作者：
Morimoto,C;Schlossman,SF
系统性红斑狼疮(SLE)被认为是典型的自身免疫性疾病，其特征是自发产生多种自身抗体，包括与淋巴细胞反应的抗体(1)。由于SLE患者表现为淋巴细胞减少(2)和T细胞功能受损(3，4)，长期以来人们一直在寻找抗淋巴细胞抗体与T细胞功能受损之间的关系。据报道，许多SLE患者存在T抑制细胞功能缺陷(5-7)。此外，还试图将T抑制细胞的功能障碍与抗淋巴细胞抗体的特异性反应联系起来(8-10)。除了抑制细胞功能障碍外，SLE患者还可能存在诱导细胞功能缺陷，伴随或独立于抑制细胞异常(11)。由于诱导细胞是诱导多种细胞功能(12、13)所必需的，这些细胞的缺陷可能导致B细胞抗体产生缺陷、T细胞介导的效应功能和/或抑制细胞功能的缺陷。后一点在SLE患者的自体混合淋巴细胞反应(AMLR)缺陷中得到说明(14)。虽然这种缺陷与抑制细胞功能缺陷有关，但现在清楚的是，AMLR和抑制因子都是
Systemic lupus erythematosus (SLE), considered the quintessential autoimmune disease, is characterized by the spontaneous production of multiple autoantibodies, including antibodies reactive with lymphocytes (1). Since patients with SLE manifest lymphopenia (2) and impaired T cell function (3, 4), a relationship between the antilymphocyte antibodies and the impaired T cell function has long been sought. Defective T suppressor cell function has been reported in many patients with SLE (5-7). Moreover, an attempt has been made to associate the dysfunction of T suppressor cells with the specific reactivities of antilymphocyte antibodies (8-10). In addition to suppressor cell dysfunction, a defect in inducer cell function may be present in SLE patients, concomitant with, or independent of, suppressor cell abnormalities (1 1). Since inducer cells are necessary for induction of a variety of cellular functions (12, 13), a defect in these cells could underlie defects in B cell antibody production, T cell-mediated effector functions, and/or suppressor cell functions. This latter point is illustrated by the defect in the autologous mixed lymphocyte reaction (AMLR) in patients with SLE (14). Although this defect has been associated with a defect in suppressor cell function, it is now clear that both the AMLR and the suppressor