Continual Gram-Negative Bacterial Challenge Accelerates Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats
Continual Gram-Negative Bacterial Challenge Accelerates Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats
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DOI：
10.3109/10641963.2012.689042
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发表时间：
2013-01-01
影响因子：
12.3
通讯作者：
Maeno, Masao
中科院分区：
文献类型：
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作者：
Kawato, Takayuki;Tanaka, Hideki;Maeno, Masao
这项研究考察了持续的革兰氏阴性细菌激发对卒中发病的影响。注射革兰氏阴性杆状细菌悬浮液或脂多糖(LPS)的易卒中自发性高血压大鼠(SHRSP)发生中风的时间明显早于未注射的对照组。在卒中发作期间，注射内毒素的SHRSP组观察到后肢瘫痪、勃起、运动减退和运动亢进，而未注射的对照组没有观察到。SHRSP组大鼠血清NOx、硫代巴比妥酸反应物和8-羟基脱氧鸟苷水平升高。这些结果表明，持续的革兰氏阴性细菌攻击导致SHRSP卒中发病加速，可能是由LPS产生的氧化应激反应引起的。
This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in stroke-prone spontaneously hypertensive rats (SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides (LPSs) than in uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in LPS-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, thiobarbituric acid reactive substance, and 8-hydroxydeoxyguanosine increased in LPS-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from LPSs.