Neural control of salivary glands in ixodid ticks.
Neural control of salivary glands in ixodid ticks.
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蜱蜱唾液腺的神经控制。
DOI：
10.1016/j.jinsphys.2011.11.006
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发表时间：
2012
影响因子：
2.2
通讯作者：
Park,Yoonseong
中科院分区：
文献类型：
--
作者：
Šimo,Ladislav;Zitňan,Dušan;Park,Yoonseong
在过去的40年里，对扁虱唾液腺(SGS)及其成分的研究产生了许多有趣的发现。然而，控制SG分泌的精确神经和生理机制仍然是个谜。有关SG控制的主要研究已经确定和表征了许多激活唾液分泌的药理和生物化合物，包括多巴胺(DA)、章鱼胺、γ-氨基丁酸、麦角生物碱、匹罗卡品(PC)及其药理相关物。具体地说，DA在不同物种中显示出最强劲的活性，其对SGS下游作用的影响已被广泛研究。我们最近在SG多巴胺受体方面的工作有助于对以前的药理学研究进行新的解释，并为SG的调控机制提供了新的概念。此外，我们最近的研究表明，多种神经肽参与了SG的控制。在到达II型和III型腺泡基底细胞的神经投射中，已经发现了肌抑制肽(MIP)和SIFamide。色素分散因子(PDF)免疫反应阳性的神经投射到达II型腺泡，RFamide和速激肽免疫反应阳性的神经投射到达SG导管，但后三种免疫反应物质的化学性质尚不清楚。在这里，我们简要回顾了以前的药理学研究，并提供了修订后的扁虱SG控制机制的摘要。
Studies of tick salivary glands (SGs) and their components have produced a number of interesting discoveries over the last four decades. However, the precise neural and physiological mechanisms controlling SG secretion remain enigmatic. Major studies of SG control have identified and characterized many pharmacological and biological compounds that activate salivary secretion, including dopamine (DA), octopamine, γ-aminobutyric acid (GABA), ergot alkaloids, pilocarpine (PC), and their pharmacological relatives. Specifically, DA has shown the most robust activities in various tick species, and its effect on downstream actions in the SGs has been extensively studied. Our recent work on a SG dopamine receptor has aided new interpretations of previous pharmacological studies and provided new concepts for SG control mechanisms. Furthermore, our recent studies have suggested that multiple neuropeptides are involved in SG control. Myoinhibitory peptide (MIP) and SIFamide have been identified in the neural projections reaching the basal cells of acini types II and III. Pigment-dispersing factor (PDF)-immunoreactive neural projections reach type II acini, and RFamide- and tachykinin-immunoreactive projections reach the SG ducts, but the chemical nature of the latter three immunoreactive substances are unidentified yet. Here, we briefly review previous pharmacological studies and provide a revised summary of SG control mechanisms in ticks.