Dendritic-cell function in Toll-like receptor- and MyD88 knockout mice
Dendritic-cell function in Toll-like receptor- and MyD88 knockout mice
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DOI：
10.1016/s1471-4906(00)01811-1
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发表时间：
2001-02-01
影响因子：
16.8
通讯作者：
Akira, S
中科院分区：
文献类型：
--
作者：
Kaisho, T;Akira, S
基于最近在髓样分化因子88（MyD88）和Toll样受体（TLR）敲除小鼠中的发现，Tsuneyasu Kaisho和Shizuo Akira讨论了TLR和MyD88在树突状细胞（DC）成熟和细胞因子产生中的作用。脂多糖结合TLR4，并可以在MyD88不存在的情况下诱导DC成熟，而CpG DNA结合TLR9，并以MyD88依赖的方式诱导DC成熟。
Based on recent findings in myeloid differentiation factor 88 (MyD88)- and Toll-like receptor (TLR)-knockout mice, Tsuneyasu Kaisho and Shizuo Akira discuss the roles of TLRs and MyD88 in dendritic cell (DC) maturation and cytokine production. Lipopolysaccharide binds TLR4 and can induce DC maturation in the absence of MyD88, whereas CpG DNA binds TLR9 and induces DC maturation in a MyD88-dependent manner.