Alteration of the gut microbiome in first-episode drug-naive and chronic medicated schizophrenia correlate with regional brain volumes
Alteration of the gut microbiome in first-episode drug-naive and chronic medicated schizophrenia correlate with regional brain volumes
复制标题
首发未用药和慢性药物治疗精神分裂症肠道微生物组的改变与区域脑容量相关
DOI：
10.1016/j.jpsychires.2020.02.005
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发表时间：
2020-04-01
影响因子：
4.8
通讯作者：
Chen, Xiaogang
中科院分区：
文献类型：
--
作者：
Ma, Xiaoqian;Asif, Huma;Chen, Xiaogang
人类肠道微生物群在中枢神经系统的基本神经发育过程中发挥着重要作用，并与一些神经精神疾病有关。然而，肠道微生物群与精神分裂症(SCZ)的潜在发病机制之间的联系尚不清楚。我们用16S rRNA基因序列分析了40例首发新药初发SCZ(FSCZ)患者、85例慢性抗精神病治疗SCZ(TSCZ)患者和69例健康对照(HCS)的粪便样本，以确定肠道微生物群的改变是否与SCZ或抗精神病药物治疗有关。此外，我们通过使用结构磁共振成像来获得T1加权的脑成像数据，以测试微生物组成是否与结构脑特征相关。我们的分析显示，与HCS相比，TSCZ患者的微生物组α多样性指数较低，而FSCZ患者的微生物组α多样性指数较低。重要的是，与HCS相比，FSCZ和TSCZ患者在某些分类群上的肠道微生物组成都发生了明显的变化，包括克里斯滕纳科、肠杆菌科、巴氏杆菌科、乳杆菌科和属水平的大肠杆菌。我们还发现，与FSCZ患者相比，TSCZ患者的肠道微生物组成存在显著的紊乱(例如。肠球菌科和乳杆菌科)。最有趣的是，我们的探索性分析发现，特定的SCZ相关微生物区系与右额中回(RMFG)的体积相关，这在SCZ患者中是异常的。我们的发现扩展了先前的工作，并表明肠道微生物群和脑结构之间可能存在联系，这可能与SCZ的病理有关。
The human gut microbiome plays an important role in the basic neurodevelopmental processes of the central nervous system and has been implicated in several neuropsychiatric disorders. However, the connection between the gut microbiome and the underlying pathogenesis of schizophrenia (SCZ) is poorly defined. Here we analyzed the faecal samples from 40 first-episode drug-naive SCZ (FSCZ) patients, 85 chronically antipsychotic-treated SCZ (TSCZ) patients and 69 healthy controls (HCs) using 16S rRNA gene sequence to determine whether the alterations of the gut microbiome were associated with SCZ or antipsychotic treatment. In addition, we acquired the T1-weighted brain imaging data by using structural magnetic resonance imaging to test whether microbial composition correlated with structural brain signatures. Our analyses revealed low microbiome alpha-diversity indexes in TSCZ patients but not in FSCZ patients as compared to HCs. Importantly, both FSCZ and TSCZ patients had distinct changes in gut microbial composition at certain taxa including Christensenellaceae, Enterobacteriaceae, Pasteurellaceae, Turicibacteraceae at the family level and Escherichia at genus level as compared to HCs. We also found significant disturbances of gut microbial composition in TSCZ versus FSCZ patients (eg. Enterococcaceae and Lactobacillaceae). Most interestingly, our exploratory analyses found specific SCZ-associated microbiota to be correlated with the right middle frontal gyrus (rMFG) volume which was aberrant in SCZ patients. Our findings extend prior work and suggest a possible link between the gut microbiome and brain structure which may be implicated in the pathology of SCZ.