FUNCTIONAL DISSECTION OF THE DROSOPHILA MUSHROOM BODIES BY SELECTIVE FEMINIZATION OF GENETICALLY DEFINED SUBCOMPARTMENTS
FUNCTIONAL DISSECTION OF THE DROSOPHILA MUSHROOM BODIES BY SELECTIVE FEMINIZATION OF GENETICALLY DEFINED SUBCOMPARTMENTS
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DOI：
10.1016/0896-6273(95)90064-0
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发表时间：
1995-07-01
期刊：
影响因子：
16.2
通讯作者：
KAISER, K
中科院分区：
文献类型：
--
作者：
ODELL, KMC;ARMSTRONG, JD;KAISER, K
人们对特定性别行为背后的神经回路知之甚少。我们已经在雄性果蝇大脑的遗传亚区表达了女性化基因转换器，特别是在蘑菇体的不同区域。蘑菇体是进化上保守的昆虫大脑中心，与联想学习和行为的其他各个方面有关。在标记蘑菇体固有神经元某些子集的线条和标记触角叶组成部分的线条上，转换器的表达会导致雄性表现出一视同仁的性行为：除了向雌性求偶外，他们还会追求成熟的配偶。在其他蘑菇体结构域和中心线中，变压器的表达没有这种影响。我们的数据支持这样的观点，即基因定义的蘑菇体内在神经元亚群发挥不同的功能作用。
Relatively little is known about the neural circuitry underlying sex-specific behaviors. We have expressed the feminizing gene transformer in genetically defined subregions of the brain of male Drosophila, and in particular within different domains of the mushroom bodies. Mushroom bodies are phylogenetically conserved insect brain centers implicated in associative learning and various other aspects of behavior. Expression of transformer in lines that mark certain subsets of mushroom body intrinsic neurons, and in a line that marks a component of the antennal lobe, causes males to exhibit nondiscriminatory sexual behavior: they court mature mates in addition to females. Expression of transformer in other mushroom body domains, and in central lines, has no such effect. Our data support the view that genetically defined subsets of mushroom body intrinsic neurons perform different functional roles.