Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice
Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice
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DOI：
10.1099/jmm.0.016873-0
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发表时间：
2010-04-01
影响因子：
3
通讯作者：
Chhibber, Sanjay
中科院分区：
文献类型：
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作者：
Bansal, Shruti;Chhibber, Sanjay
由急性肺部感染引起的急性肺损伤仍然是死亡的主要原因。因此，抗生素和具有免疫调节和抗炎活性的化合物的组合可以帮助克服急性肺部感染引起的损伤。来源于姜黄根茎的姜黄素已经使用了几十年，它通过下调各种炎症介质而表现出抗炎、抗癌、免疫调节特性。考虑到这些特性，我们通过鼻内途径将肺炎克雷伯氏菌B5055引入BALB/c小鼠，研究了姜黄素在急性炎症小鼠模型中的抗炎特性。在急性肺炎诱导炎症的小鼠模型中鼻内滴注细菌导致肺中中性粒细胞浸润显著增加，沿着肺组织中各种炎症介质[即丙二醛（MDA）、髓过氧化物酶（MPO）、一氧化氮（NO）、肿瘤坏死因子（INF）-α]的产生增加。在通过鼻内途径将细菌滴入肺内之前15天，单独口服姜黄素或姜黄素与Augmentin联合给药的动物显示出显著的（P
Acute lung injuries due to acute lung infections remain a major cause of mortality. Thus a combination of an antibiotic and a compound with immunomodulatory and anti-inflammatory activities can help to overcome acute lung infection-induced injuries. Curcumin derived from the rhizome of turmeric has been used for decades and it exhibits anti-inflammatory, anti-carcinogenic, immunomodulatory properties by downregulation of various inflammatory mediators. Keeping these properties in mind, we investigated the anti-inflammatory properties of curcumin in a mouse model of acute inflammation by introducing Klebsiella pneumoniae B5055 into BALB/c mice via the intranasal route. Intranasal instillation of bacteria in this mouse model of acute pneumonia-induced inflammation resulted in a significant increase in neutrophil infiltration in the lungs along with increased production of various inflammatory mediators [i.e. malondialdehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), tumour necrosis factor (INF)-alpha] in the lung tissue. The animals that received curcumin alone orally or in combination with augmentin, 15 days prior to bacterial instillation into the lungs via the intranasal route, showed a significant (P