TUMOR-LOCALIZING AND PHOTOSENSITIZING PROPERTIES OF HEMATOPORPHYRIN DERIVATIVE IN HAMSTER BUCCAL POUCH CARCINOMA
TUMOR-LOCALIZING AND PHOTOSENSITIZING PROPERTIES OF HEMATOPORPHYRIN DERIVATIVE IN HAMSTER BUCCAL POUCH CARCINOMA
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DOI：
10.1016/0030-4220(86)90421-4
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发表时间：
1986-04-01
期刊：
影响因子：
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通讯作者：
GOLDBLATT, PJ
中科院分区：
文献类型：
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作者：
BURNS, RA;KLAUNIG, JE;GOLDBLATT, PJ
研究了血卟啉衍生物（HPD）在7,12二甲苯并蒽（DMBA）诱导的叙利亚仓鼠口腔癌中的肿瘤定位和光化学治疗特性。注射HPD的仓鼠口腔肿瘤(50 .mu。腹腔注射HPD 24小时后，暴露在长波紫外线下，显示出明亮的橙红色荧光。邻近无肿瘤粘膜未见荧光。同样，未用HPD治疗的肿瘤、用HPD治疗的正常粘膜和未用HPD治疗的正常粘膜也没有荧光。在接受HPD和光化学疗法（PCT）的动物中，检查光化学疗法后的大体和微观病理变化。肿瘤表现为水肿、出血和细胞坏死，随光化学治疗后采样时间的延长而进展。大多数口腔肿瘤在HPD PCT后24小时出现明显的肿瘤坏死。
The tumor-localizing and photochemotherapeutic properties of hematoporphyrin derivative (HPD) were examined in 7,12 dimethylbenzanthracene (DMBA)-induced oral cancers in the Syrian hamster. Oral tumors in hamsters injected with HPD (50 .mu.g per gram of body weight) exhibited bright salmon pink fluorescence when exposed to long-wave ultraviolet light 24 hours after intraperitoneal HPD injection. Adjacent tumor-free mucosa did not fluoresce. Similarly, tumors not treated with HPD, normal mucosa treated with HPD, and normal mucosa not treated with HPD did not fluoresce. Tumors in animals that received HPD and photochemotherapy (PCT) were examined for gross and microscopic pathologic changes following the phototreatment. Tumors displayed edema, hemorrhage, and cellular necrosis that progressed with the time of sampling after photochemotherapy. Complete tumor necrosis was evident in the majority of oral tumors 24 hours after HPD PCT.