Lumpy skin disease in Ethiopia: Seroprevalence study across different agro-climate zones
Lumpy skin disease in Ethiopia: Seroprevalence study across different agro-climate zones
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DOI：
10.1016/j.actatropica.2012.04.009
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发表时间：
2012-08-01
期刊：
影响因子：
2.7
通讯作者：
Roger, F.
中科院分区：
文献类型：
--
作者：
Gari, G.;Grosbois, V.;Roger, F.
进行了一项横断面研究，以估计埃塞俄比亚不同农业气候区的块状皮肤病（LSD）的血清流行率。共采集15个区42个科贝勒人血清样本2368份，采用间接荧光抗体试验（IFAT）和病毒中和试验（VNT）进行检测。使用贝叶斯模型估计了每个农业气候区的牛群和动物真正的 LSD 血清学流行率。使用随机效应模型评估簇内相关系数（ICC）。根据血清学流行率估计，LSD 对所考虑的三个农业气候区的影响不同。中部农业气候区的牛群水平血清阳性率较高，为 64%（95% CI：53-74），而高地农业气候区为 26%（95% CI：17-36），低地农业气候区为 50%（95% CI：40-60）。中部农业气候区受感染牛群的动物水平血清阳性率也高于高地和低地地区（分别为 24%（95% CI：18-31）和 23%（95% CI：18-29）），分别为 31%（95% CI：24-40）。高地农业气候区的 ICC 值较高，意味着在未来的研究中，该地区特别需要增加样本量，以达到所需的精度水平来估计 LSD 流行率或发病率。这项血清流行率研究还表明，埃塞俄比亚 LSD 感染流行率高于之前报道的水平。根据这些最新的估计，我们讨论了未来触发适当控制措施的选项。 (C) 2012 Elsevier B.V. 保留所有权利。
A cross-sectional study was conducted to estimate the seroprevalence of lumpy skin disease (LSD) in the different agro-climatic zones prevailing in Ethiopia. A total of 2368 serum samples were collected from 42 kebeles located in 15 districts and tested using indirect fluorescent antibody test (IFAT) and virus neutralization test (VNT). The herd and animal true LSD serological prevalence were estimated in each agro-climate zone using a Bayesian model. The intra-cluster correlation coefficient (ICC) was evaluated using a random-effect model. According to the serological prevalence estimations, LSD affected differently the three agro-climatic zones considered. Herd level seroprevalence was higher in the midland agro-climate zone 64% (95% CI: 53-74) as compared to the highland 26% (95% CI: 17-36) and the lowland 50% (95% CI: 40-60) agro-climates. Animal level seroprevalence in infected herds was also higher in the midland agro-climate zone 31% (95% CI: 24-40) than in the highland and lowland zones (24% (95% CI: 18-31) and 23% (95% CI: 18-29), respectively). Higher ICC value in the highland agro-climate zone implies that increased sample sizes should be particularly required for this zone in future studies to estimate LSD prevalence or incidence with a desired precision level. This seroprevalence study also suggests that the prevalence of LSD infection in Ethiopia is higher than what has been previously reported. In the light of these updated estimations, we discuss options to trigger appropriate control measures in the future. (C) 2012 Elsevier B.V. All rights reserved.