Changes in Haemostatic Factors and Activation Products after Exercise in Healthy Subjects with Different Ages
Changes in Haemostatic Factors and Activation Products after Exercise in Healthy Subjects with Different Ages
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不同年龄健康受试者运动后止血因子及激活产物的变化
DOI：
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发表时间：
1995
影响因子：
6.7
通讯作者：
I. Huisveld
中科院分区：
文献类型：
--
作者：
P. van den Burg;J. Hospers;M. van Vliet;W L Mosterd;B. Bouma;I. Huisveld
我们研究了不同年龄组运动引起的凝血和纤溶因子及活化产物的变化。将38只久坐不动的雄性动物分为3个年龄组（猫I-III; 20-30岁、35-45岁和50-60岁），进行标准化运动试验。FVII：c（105 ± 5、121 ±6和123 ± 7% NP）、纤维蛋白原（2.35 ± 0.12、2.55 ± 0.10和2.66 ± 0.09 mg/ml）、凝血酶原激活片段F1+2（0.80 ± 0.10、0.80 ± 0.11和1.22 ±0.16 nM）、t-PA（5.2 ± 0.6、9.2 ± 1.0、8.6 ± 1.2 ng/ml）和派-1（42.8 ± 7.5、67.6 ± 7.6、62.2 ± 10.9 ng/ml）的运动前水平（猫I-III分别）显示出似乎与年龄相关的差异。回归分析显示与人体测量（FVII：c，纤维蛋白原，F1+2，t-PA，派-1），而不是与年龄的关联。三个年龄组中，凝血功能（von Wille-brand因子和FVIII：c增加，APTT缩短）和纤溶潜能（t-PA和u-PA增加）的变化幅度相当。F1+2（6%）几乎没有任何变化，而凝血酶-抗凝血酶复合物（93%），纤溶酶-抗纤溶酶复合物（79%）和D-二聚体（77%）几乎增加了一倍，在最大的运动。我们的结论是，人体测量的差异发挥更显着的作用比年龄的止血因素的组成水平在60岁以下的参与者。运动引起的变化的幅度在研究的年龄组中是相当的，并且简单地叠加在本构（运动前）水平上。缺乏凝血酶原激活的明确证据，但纤溶酶的形成在运动中增强。
Summary We studied exercise-induced changes in coagulation and fibrinolytic factors and activation products in different age categories. Thirty-eight sedentary males, divided in three age categories (cats I-III; 20-30, 35-45 and 50-60 y) were subjected to a standardized exercise test. Pre-exercise levels (cats I-III resp) of FVII:c (105 ± 5, 121 ±6 and 123 ± 7% NP), fibrinogen (2.35 ± 0.12, 2.55 ± 0.10 and 2.66 ± 0.09 mg/ml), prothrombin activation fragment F1+2 (0.80 ± 0.10,0.80 ± 0.11 and 1.22 ±0.16 nM), t-PA (5,2 ± 0.6, 9.2 ± 1.0, 8.6 ± 1.2 ng/ml) and PAI-1 (42.8 ± 7.5, 67.6 ± 7.6, 62.2 ± 10.9 ng/ml) showed differences that seemed related to age. Regression analysis revealed associations with anthropometry (FVII:c, fibrinogen, F1+2, t-PA, PAI-1) rather than with age. Exercise-induced changes in coagulation (increase in von Wille-brand factor and FVIII:c and a shortening of APTT) and fibrinolytic potential (increase in t-PA and u-PA) were of comparable magnitude for the three age categories. Hardly any change in F1+2 (6%) was observed, while thrombin-antithrombin complexes (93%), plasmin-antiplasmin complexes (79%) and D-dimer (77%) almost doubled during maximal exercise. We conclude that anthropometric differences play a more significant role than age on constitutive levels of haemostatic factors in participants up to 60 years of age. The magnitude of exercise-induced changes is comparable in the age categories under study, and simply superimposed on constitutive (pre-exercise) levels. Clear evidence for prothrombin activation is lacking, but plasmin formation is enhanced during exercise.
纤维蛋白血栓和可溶性血浆衍生物的凝血酶活性。
DOI：
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发表时间：
1983
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Francis,CW;MarkhamJr,RE;Barlow,GH;Florack,TM;Dobrzynski,DM;Marder,VJ
通讯作者：
Marder,VJ
影响因子：
20.3
作者：
K. Bauer;K. Bauer;R. Rosenberg;R. Rosenberg
通讯作者：
K. Bauer;K. Bauer;R. Rosenberg;R. Rosenberg
人体的运动和止血。
影响因子：
3.6
作者：
Streiff,M;Bell,WR
通讯作者：
Bell,WR