Place representation within hippocampal networks is modified by long-term potentiation
Place representation within hippocampal networks is modified by long-term potentiation
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DOI：
10.1016/s0896-6273(03)00465-3
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发表时间：
2003-08-28
期刊：
影响因子：
16.2
通讯作者：
Buzsáki, G
中科院分区：
文献类型：
--
作者：
Dragoi, G;Harris, KD;Buzsáki, G
在大脑中，信息由神经元集合的放电模式和单个神经元之间突触连接的强度编码。我们在这里报告的代表性的环境中的“位置”细胞改变海马网络内的突触权重。内在海马通路的长时程增强（LTP）消除了现有的位置场，创造了新的位置场，并重新安排了受影响人群的时间关系。LTP对神经元放电的影响具有频率和背景依赖性。LTP诱导的“重新映射”发生时，不会影响网络的全局放电率。这些发现支持了这样的观点，即学习的位置表征可以通过海马内网络的LTP样突触可塑性来完成。
In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP) of intrinsic hippocampal pathways abolished existing place fields, created new place fields, and rearranged the temporal relationship within the affected population. The effect of LTP on neuron discharge was rate and context dependent. The LTP-induced "remapping" occurred without affecting the global firing rate of the network. The findings support the view that learned place representation can be accomplished by LTP-like synaptic plasticity within intrahippocampal networks.