Functions of mammalian Polycomb group and trithorax group related genes
Functions of mammalian Polycomb group and trithorax group related genes
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DOI：
10.1016/s0959-437x(97)80075-5
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发表时间：
1997-08-01
影响因子：
4
通讯作者：
Gould, A
中科院分区：
文献类型：
--
作者：
Gould, A
聚梳类和三胸类基因(PcG和trxG)是细胞记忆系统的一部分，在果蝇中维持同源异型基因表达的非活跃和活跃状态。最近的遗传学证据表明，哺乳动物中的几个相关基因也参与了HOX基因的调控。与果蝇一样，脊椎动物的基因产物是调节转录激活抑制和染色质结构方面的多蛋白复合体的组成部分，初步迹象表明，存在一个大型哺乳动物PcG和trxG家族，有可能编码细胞晚期和细胞周期控制的多种特殊功能。
Genes of the Polycomb and trithorax groups (PcG and trxG) are part of a cellular memory system that maintains inactive and active states of homeotic gene expression in Drosophila. Recent genetic evidence indicates that several related loci in mammals are also involved in the regulation of Hox genes. Like their Drosophila counterparts, the vertebrate gene products are components of multiprotein complexes that regulate transcriptional activation repression and aspects of chromatin structure, Initial indications suggest the existence of a large mammalian PcG and trxG family, with a potential to encode multiple specialised functions in cell late and cell-cycle control.