The Acute Phase Response Affected Traditional Measures of Micronutrient Status in Rural Zambian Children during a Randomized, Controlled Feeding Trial
The Acute Phase Response Affected Traditional Measures of Micronutrient Status in Rural Zambian Children during a Randomized, Controlled Feeding Trial
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DOI：
10.3945/jn.114.192245
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发表时间：
2014-06-01
影响因子：
4.2
通讯作者：
Tanumihardjo, Sherry A.
中科院分区：
文献类型：
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作者：
Bresnahan, Kara A.;Chileshe, Justin;Tanumihardjo, Sherry A.
对感染的急性时相反应(APR)可以改变微量营养素状态的血液指标。使用赞比亚农村儿童(n=181，年龄3-5岁)的3个月随机对照喂养试验的数据，使用基线和最终血样来确定APR对维生素A和铁状况指标的影响。急性期蛋白的浓度被归类为仅升高的C反应蛋白(C反应蛋白5和10 mg/L)，均升高的C反应蛋白和α(1)酸性糖蛋白(AGP；>；1.2g/L)，仅升高的AGP，没有升高的C反应蛋白或AGP来区分感染的各个阶段：潜伏期、早期恢复期、恢复期和健康状态。没有足够的数据来检查感染的潜伏期。C反应蛋白浓度为-gt；5 mg/L是该人群中显示对微量营养素标志物影响的一个有效的高值点。时间不影响血红蛋白、血清铁蛋白或血清视黄醇浓度(P>；0.05)。在恢复期早期，血红蛋白下降(14-16%；P
The acute phase response (APR) to infection can alter blood-based indicators of micronutrient status. Data from a 3-mo randomized, controlled feeding trial in rural Zambian children (n = 181, aged 3-5 y) were used to determine the impact of the APR on indicators of vitamin A and iron status using baseline and final blood samples. Concentrations of acute phase proteins were categorized as raised C-reactive protein (CRP; >5 and >10 mg/L) only, both raised CRP and alpha(1)-acid glycoprotein (AGP; >1.2 g/L), raised AGP only, and neither CRP nor AGP raised to identify the respective stages of infection: incubation, early convalescence, convalescence, and healthy state. Data were insufficient to examine the incubation stage of infection. A CRP concentration of >5 mg/L was an effective elevation cutoff point in this population to show impact on micronutrient markers. Time did not affect hemoglobin, serum ferritin, or serum retinol concentrations (P > 0.05). During early convalescence, hemoglobin decreased (14-16%; P