MELANIN, TYROSINE-HYDROXYLASE, CALBINDIN AND SUBSTANCE-P IN THE HUMAN MIDBRAIN AND SUBSTANTIA-NIGRA IN RELATION TO NIGROSTRIATAL PROJECTIONS AND DIFFERENTIAL NEURONAL SUSCEPTIBILITY IN PARKINSONS-DISEASE
MELANIN, TYROSINE-HYDROXYLASE, CALBINDIN AND SUBSTANCE-P IN THE HUMAN MIDBRAIN AND SUBSTANTIA-NIGRA IN RELATION TO NIGROSTRIATAL PROJECTIONS AND DIFFERENTIAL NEURONAL SUSCEPTIBILITY IN PARKINSONS-DISEASE
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DOI：
10.1016/0006-8993(92)90719-p
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发表时间：
1992-05-29
期刊：
影响因子：
2.9
通讯作者：
GIBB, WRG
中科院分区：
文献类型：
--
作者：
GIBB, WRG
酪氨酸羟化酶（TH），钙结合蛋白D28 k，和P物质免疫染色的含黑色素的神经元和其他中脑结构的解剖进行了检查。黑质黑色素细胞中有95%以上含有黑色素，但腹侧层中密集细胞的黑色素含量较低，背侧层中松散细胞的黑色素含量较高。大约60%的γ-组和40%的红核后黑色素含量低。TH免疫染色在腹侧和背侧层都是中等的，但在γ组和红核后更强烈。Calbindin D28 k在腹侧和背侧层中不存在，但在γ组和红核后存在。根据灵长类动物的追踪研究，这些发现表明，腹侧层的峡部项目的纹状体和背侧层，γ-组和红核后的基质室。在帕金森病中，腹侧层比背侧层更脆弱，但细胞含有较少的黑色素。两层均不含钙结合蛋白D28 k。腹侧和背侧层之间的这种差异脆弱性不能用黑色素或钙结合蛋白D28 k来解释。
The anatomy of melanin-containing neurons and other midbrain structures was examined by tyrosine hydroxylase (TH), calbindin D28k, and substance P immunostaining. Greater than 95% of cells in the substantia nigra pars compacta contained melanin, but densely packed cells in a ventral tier had a low content of melanin and loosely packed cells in a dorsal tier had a high content of melanin. Approximately 60% in the gamma-group and 40% in the retrorubral nucleus had a low content of melanin. TH immunostaining was moderate in both the ventral and dorsal tiers, but more intense in the gamma-group and retrorubral nucleus. Calbindin D28k was absent from the ventral and dorsal tiers, but present in the gamma-group and retrorubral nucleus. In the light of primate tracing studies these findings suggest that the ventral tier of the pars compacta projects to striosomes of the striatum and the dorsal tier, gamma-group and retrorubral nucleus to the matrix compartment. The ventral tier is more vulnerable than the dorsal tier in Parkinson's disease, but the cells contain less melanin. Neither tier contains calbindin D28k. This differential vulnerability between the ventral and dorsal tiers cannot be explained by melanin or calbindin D28k.