Diet-induced changes in subcutaneous adipose tissue blood flow in man: effect of beta-adrenoceptor inhibition.
Diet-induced changes in subcutaneous adipose tissue blood flow in man: effect of beta-adrenoceptor inhibition.
复制标题
饮食引起的人体皮下脂肪组织血流变化：β-肾上腺素受体抑制的作用。
DOI：
10.1111/j.1748-1716.1990.tb08932.x
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
N. Christensen
中科院分区：
文献类型：
--
作者：
L. Simonsen;J. Bülow;A. Astrup;J. Madsen;N. Christensen
在连续和不连续静脉注射的情况下，研究了高碳水化合物饮食对皮下脂肪组织血流的影响。普萘洛尔在健康志愿者中的输注。用~(133)Xe洗脱法测量前臂、大腿和腹部三个部位的皮下脂肪组织血流量。受试者被给予由白面包、果酱、蜂蜜和苹果汁组成的一餐(约2300千焦耳)。这顿饭导致被检查组织的血流量增加了两倍。心得安消除了大腿和腹部的流量增加，减少了前臂的流量。这表明血流增加的机制是由皮下脂肪组织中血管β-肾上腺素受体的刺激引起的，因为β-肾上腺素受体抑制并不影响对食物的整体代谢和激素反应。
The effect of a carbohydrate-rich meal on subcutaneous adipose tissue blood flow was studied with and without continuous i.v. infusion of propranolol in healthy volunteers. The subcutaneous adipose tissue blood flow was measured with the 133Xe washout method in three different locations: the forearm, the thigh and the abdomen. The subjects were given a meal consisting of white bread, jam, honey and apple juice (about 2300 kJ). The meal induced a twofold increase in blood flow in the examined tissues. Propranolol abolished the flow increase in the thigh and the abdomen and reduced it in the forearm. This indicates that the mechanism for the flow increase is elicited by a stimulation of vascular beta-adrenoceptors in the subcutaneous adipose tissue, since the beta-adrenoceptor inhibition did not affect the overall metabolic and hormonal responses to the meal.