Plasma nicotine levels produced by chewing nicotine gum.
Plasma nicotine levels produced by chewing nicotine gum.
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咀嚼尼古丁口香糖产生的血浆尼古丁水平。
DOI：
10.1001/jama.1982.03330070053030
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
K. McCusker
中科院分区：
文献类型：
--
作者：
M. McNabb;R. Ebert;K. McCusker
尼古丁口香糖的目的是在戒烟过程中维持血浆尼古丁水平，同时个体应对吸烟的重复行为成分的丧失。在9名肺部疾病患者中，将每小时咀嚼口香糖获得的血浆尼古丁水平与吸烟获得的水平进行了比较。每小时咀嚼2 mg和4 mg尼古丁口香糖产生的平均稳态血浆尼古丁水平分别为11.8和23.2 ng/mL。相比之下，正常吸烟期间的平均血浆尼古丁谷水平为15.7 ng/mL，每小时吸烟一根香烟的平均谷水平为18.3 ng/mL，尼古丁产量为1.1 mg。使用2-或4-mg口香糖几乎没有副作用。在一项短期研究中，尼古丁口香糖被证明是一种可接受的尼古丁来源，有助于戒烟。
Nicotine chewing gum is designed to maintain plasma nicotine levels during a smoking cessation effort while the individual copes with the loss of the repetitive behavioral components of smoking. The plasma nicotine levels obtained with hourly gum chewing were compared with levels obtained with cigarette smoking in nine patients with lung disease. Chewing 2- and 4-mg nicotine gum hourly produced mean steady-state plasma nicotine levels of 11.8 and 23.2 ng/mL, respectively. This compares with a mean plasma nicotine trough level during usual smoking of 15.7 ng/mL and a mean trough level of 18.3 ng/mL with hourly smoking of a cigarette with a nicotine yield of 1.1 mg. Few side effects were seen with the use of either the 2- or 4-mg gum. In a short-term study, nicotine gum proved an acceptable source of nicotine for aiding smoking cessation.