Sperm penetration through cumulus mass and zona pellucida
Sperm penetration through cumulus mass and zona pellucida
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DOI：
10.1387/ijdb.072528ek
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发表时间：
2008-01-01
影响因子：
0.7
通讯作者：
Baba, Tadashi
中科院分区：
文献类型：
--
作者：
Kim, Ekyune;Yamashita, Misuzu;Baba, Tadashi
哺乳动物的受精需要精子在与卵子融合之前穿透卵丘和卵透明膜。虽然精子穿透这些物理屏障是必不可少的，但其分子机制尚未完全阐明。除了精子活力外，精子的透明质酸水解酶和蛋白水解酶也被认为参与了穿透事件。在这里，我们专注于透明质酸酶和蛋白酶在精子通过卵丘质量和透明质膜的功能作用。
Mammalian fertilization requires sperm to penetrate the cumulus mass and egg zona pellucida prior to fusion with the egg. Although sperm penetration through these physical barriers is essential, the molecular mechanism has not yet been completely elucidated. In addition to sperm motility, hyaluronan-hydrolyzing and proteolytic enzymes of sperm have been suggested to participate in the penetration events. Here we focus on the functional roles of hyaluronidase and protease in sperm passage through the cumulus mass and zona pellucida.