Integration of sensory and reward information during perceptual decision-making in lateral intraparietal cortex (LIP) of the macaque monkey.
Integration of sensory and reward information during perceptual decision-making in lateral intraparietal cortex (LIP) of the macaque monkey.
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DOI：
10.1371/journal.pone.0009308
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发表时间：
2010-02-19
期刊：
影响因子：
3.7
通讯作者：
Newsome WT
中科院分区：
文献类型：
--
作者：
Rorie AE;Gao J;McClelland JL;Newsome WT
众所周知，皮层 LIP 区域的单个神经元携带与眼球运动报告的感觉和基于价值的决策相关的信息。然而，当个人决策必须基于这些变量的组合时，尚不清楚 LIP 中如何将感官和价值信息结合起来。为了研究这个问题，我们在恒河猴中进行了行为和电生理学实验，实验期间对运动方向（感觉成分）进行了两种选择的强制选择辨别。猴子通过对与两个可能的运动方向相关的两个视觉目标之一进行眼球运动来报告每个决定。我们通过将平衡奖励条件（两种选择的奖励值相等）与不平衡条件（一种选择的价值是另一种选择的两倍）随机交织，将选择偏差引入猴子的决策过程（价值成分）。猴子的行为以及大多数唇神经元的行为反映了所有相关变量的影响：感觉信息的强度、神经元响应场中目标的值以及响应场外目标的值。总体而言，详细分析和计算机模拟表明，我们的数据与 Diederich 和 Bussmeyer 提出的两阶段漂移扩散模型一致，该模型适用于感觉辨别任务背景下的收益效应。回报信息的初始处理强烈影响感官证据积累的起点，而对感官证据积累的速率影响很小（如果有的话）。
Single neurons in cortical area LIP are known to carry information relevant to both sensory and value-based decisions that are reported by eye movements. It is not known, however, how sensory and value information are combined in LIP when individual decisions must be based on a combination of these variables. To investigate this issue, we conducted behavioral and electrophysiological experiments in rhesus monkeys during performance of a two-alternative, forced-choice discrimination of motion direction (sensory component). Monkeys reported each decision by making an eye movement to one of two visual targets associated with the two possible directions of motion. We introduced choice biases to the monkeys' decision process (value component) by randomly interleaving balanced reward conditions (equal reward value for the two choices) with unbalanced conditions (one alternative worth twice as much as the other). The monkeys' behavior, as well as that of most LIP neurons, reflected the influence of all relevant variables: the strength of the sensory information, the value of the target in the neuron's response field, and the value of the target outside the response field. Overall, detailed analysis and computer simulation reveal that our data are consistent with a two-stage drift diffusion model proposed by Diederich and Bussmeyer for the effect of payoffs in the context of sensory discrimination tasks. Initial processing of payoff information strongly influences the starting point for the accumulation of sensory evidence, while exerting little if any effect on the rate of accumulation of sensory evidence.
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DOI：
10.1016/b978-0-12-374176-9.00024-5
发表时间：
2009-01-01
期刊：
NEUROECONOMICS: DECISION MAKING AND THE BRAIN
影响因子：
--
作者：
Balleine, Bernard W.;Daw, Nathaniel D.;O'Doherty, John P.
通讯作者：
O'Doherty, John P.
影响因子：
1.9
作者：
BRITTEN, KH;SHADLEN, MN;MOVSHON, JA
通讯作者：
MOVSHON, JA
影响因子：
2.7
作者：
Corrado, GS;Sugrue, LP;Newsome, WT
通讯作者：
Newsome, WT
影响因子：
2.7
作者：
Gottlieb, Jacqueline;Balan, Puiu;Suzuki, Mototaka
通讯作者：
Suzuki, Mototaka
DOI：
10.1016/b978-0-12-374176-9.00032-4
发表时间：
2009-01-01
期刊：
NEUROECONOMICS: DECISION MAKING AND THE BRAIN
影响因子：
--
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.