Association between serum β-carotene-to-retinol ratio and severity of hepatic steatosis in non-alcoholic fatty liver disease in Japan: A cross-sectional study
Association between serum β-carotene-to-retinol ratio and severity of hepatic steatosis in non-alcoholic fatty liver disease in Japan: A cross-sectional study
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DOI：
10.1016/j.nut.2020.110984
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发表时间：
2020-11-01
期刊：
影响因子：
4.4
通讯作者：
Fukuda, Shinsaku
中科院分区：
文献类型：
--
作者：
Kimura, Masayo;Mikami, Kenichiro;Fukuda, Shinsaku
目的：视黄醇和β-胡萝卜素参与非酒精性脂肪性肝病（NAFLD）的发病机制。然而，临床研究有限。本研究的目的是探讨血清中β-胡萝卜素与视黄醇的比值（SC/SR）与超声诊断的NAFLD肝脂肪变性之间的关系。方法：参与者为606名日本成年人，他们参加了健康调查。分析临床特征、膳食营养摄入、血液生化、血清视黄醇和类胡萝卜素。非酒精性脂肪肝被定义为脂肪肝超声检查在没有其他原因的脂肪atosis.Results：妇女有较高的每日摄入量的α-和β-胡萝卜素，虽然有或没有非酒精性脂肪肝在男性和女性的参与者之间的每日视黄醇和类胡萝卜素的摄入量没有差异。无论是否存在NAFLD，女性的SC/SR比均高于男性，女性的SC/SR比随着肝脂肪变性的加重而降低，而男性的SC/SR比尽管肝脂肪变性加重但没有变化。调整混杂因素后，SC/SR比值最高四分位数的参与者发生NAFLD的可能性比最低四分位数的参与者降低了三分之二（调整后的比值比为0.64; 95%置信区间为0.21-1.92; P = 0.041）。SC/SR比值与血清高密度脂蛋白胆固醇水平呈正相关，与血清三酰甘油水平呈负相关。结论：NAFLD患者SC/SR比值较低，且存在性别差异，且与脂肪肝的严重程度及血脂水平相关。未来的研究需要扩大这些发现。(C)2020爱思唯尔公司All rights reserved.
Objectives: Retinol and beta-carotene have been reported to be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, clinical studies are limited. The aim of this study was to investigate the relationship between serum the ratio of beta-carotene to retinol (SC/SR) and hepatic steatosis in NAFLD diagnosed by ultrasonography.Methods: The participants were 606 Japanese adults who were enrolled in a health survey. Clinical profile, dietary nutrition intake, blood biochemistry, serum retinol, and carotenoids were analyzed. NAFLD was defined as fatty liver on ultrasonography in the absence of other causes of steatosis.Results: Women had higher daily intake of alpha- and beta-carotene, although there were no differences in daily retinol and carotenoid intake between participants with or without NAFLD in both men and women. Women had a higher SC/SR ratio than men regardless of the presence or absence of NAFLD, and the SC/SR ratio in women decreased with exacerbation of hepatic steatosis, whereas the SC/SR ratio in men did not change despite exacerbation of hepatic steatosis. After adjusting for confounding factors, the likelihood of NAFLD among participants in the highest quartile of SC/SR ratio decreased by two-thirds compared with participants in the lowest quartile (adjusted odds ratio, 0.64; 95% confidence interval, 0.21-1.92; P = 0.041). The SC/SR ratio was positively correlated with serum high-density lipoprotein cholesterol level, and negatively correlated with serum triacylglycerol level.Conclusions: The SC/SR ratio was lower in NAFLD with sex differences, and was associated with the severity of hepatic steatosis and lipid profile. Future studies are needed to expand on these findings. (C) 2020 Elsevier Inc. All rights reserved.