[PSI(+)] turns 50.
[PSI(+)] turns 50.
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[PSI( )] 已满 50 岁。
DOI：
10.1080/19336896.2015.1111508
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发表时间：
2015
期刊：
影响因子：
2.3
通讯作者：
Tuite MF
中科院分区：
文献类型：
--
作者：
Tuite MF
2015年是布赖恩·考克斯发表的一篇研究论文发表50周年，这篇论文奠定了我们对真菌朊病毒生物学的理解，即“酵母中超级抑制因子的细胞质抑制因子ψ”。在这里，我们展示了我们对[PSI+]决定因素的分子性质的理解是如何从一个“隐蔽的”决定因素演变为翻译终止因子的可传递淀粉样蛋白形式。我们还考虑到对[PSI]的研究已经并将继续对朊病毒研究产生影响。为了证明这一点，酵母朊病毒领域的主要研究人员在他们的研究中广泛使用了[PSI+]特性，他们对[PSI]的发现和意义发表了自己的评论。
The year 2015 sees the fiftieth anniversary of the publication of a research paper that underpins much of our understanding of fungal prion biology, namely “ψ,a cytoplasmic suppressor of super-suppressor in yeast” by Brian Cox. Here we show how our understanding of the molecular nature of the [PSI+] determinant evolved from an ‘occult’ determinant to a transmissible amyloid form of a translation termination factor. We also consider the impact studies on [PSI] have had – and continue to have - on prion research. To demonstrate this, leading investigators in the yeast prion field who have made extensive use of the [PSI+] trait in their research, provide their own commentaries on the discovery and significance of [PSI].