Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naïve guinea pigs.
Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naïve guinea pigs.
复制标题
反复的支气管收缩减弱了幼稚豚鼠对支气管收缩的咳嗽反应。
DOI：
10.1016/j.alit.2019.09.002
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
K. Kasahara
中科院分区：
文献类型：
--
作者：
Kenta Yamamura;Johsuke Hara;Tamami Sakai;N. Ohkura;M. Abo;Naohiko Ogawa;A. Okazaki;T. Sone;H. Kimura;M. Fujimura;S. Nakao;K. Kasahara
背景：咳嗽变异性哮喘（CVA）是支气管哮喘（BA）的先兆。然而，这些类似疾病对支气管收缩的咳嗽反应不同。反复支气管收缩和由此产生的内源性脂质介质的不平衡可能会影响咳嗽respons.Methods：我们研究了反复支气管收缩对支气管收缩的咳嗽反应的影响，使用天真的豚鼠。连续3天诱导支气管收缩，并评估咳嗽反应和BAL液（BALF）中脂质介质（如PGE 2、PGI 2和半胱氨酰-LTs（Cys-LTs））的变化。我们采用PGI 2受体拮抗剂研究了内源性PGI 2对咳嗽反应的影响。为了研究咳嗽反应在一个较长的时间，我们重新评估咳嗽反应2周后反复支气管收缩。结果：支气管收缩引起的咳嗽次数显着减少反复支气管收缩。反复收缩支气管后，PGE 2、PGI 2、Cys-LTs水平及PGI 2/PGE 2比值均显著升高。这种咳嗽反应的减少被PGI 2受体拮抗剂预处理所抑制。反复支气管收缩后2周，咳嗽反应恢复至沿着反复支气管收缩前水平，脂质介质如PGE 2、PGI 2和Cys-LTs以及PGI 2/PGE 2比值也随之恢复。我们的研究结果表明，反复的支气管收缩和由此产生的内源性脂质介质的不平衡有助于不同的咳嗽反应支气管收缩，CVA和BA。
Background: Cough variant asthma (CVA) is recognized as a precursor of bronchial asthma (BA). However, the cough response to bronchoconstriction differs between these similar diseases. Repeated bronchoconstriction and the resulting imbalance of endogenous lipid mediators may impact the cough response.Methods: We investigated the influence of repeated bronchoconstriction on the cough response to bronchoconstriction using naïve guinea pigs. Bronchoconstriction was induced for 3 consecutive days and changes in the cough response and lipid mediators, such as PGE 2, PGI 2, and cysteinyl-LTs (Cys-LTs), in BAL fluid (BALF) were assessed. We investigated the effect of endogenous PGI 2 on the cough response by employing a PGI 2 receptor antagonist. In order to investigate the cough response over a longer period, we re-evaluated the cough response 2 weeks after repeated bronchoconstriction.Results: The number of coughs induced by bronchoconstriction were significantly decreased by repeated bronchoconstriction. The levels of PGE 2, PGI 2, and Cys-LTs, and the ratio of PGI 2/PGE 2 were significantly increased, following repeated bronchoconstriction. This decrease in the cough response was suppressed by pretreatment with a PGI 2 receptor antagonist. Two weeks after repeated bronchoconstriction, the cough response returned to the same level as before repeated bronchoconstriction along with a concomitant return of lipid mediators, such as PGE 2, PGI 2, and Cys-LTs and the ratio of PGI 2/PGE 2.Conclusions: Our results suggest that repeated bronchoconstriction and the resulting imbalance of endogenous lipid mediators contribute to the difference in cough responses to bronchoconstriction in CVA and BA.
DOI：
10.1164/ajrccm.156.3.9606031
发表时间：
1997-09-01
影响因子：
24.7
作者：
Hamelmann, E;Schwarze, J;Gelfand, EW
通讯作者：
Gelfand, EW
DOI：
10.1164/ajrccm.162.3.9909064
发表时间：
2000-09-01
影响因子：
24.7
作者：
Brichtling, CE;Ward, R;Pavord, ID
通讯作者：
Pavord, ID