Effects of Aging on LH and Prolactin after LHRH L-Dopa, Methyl-Dopa, and Stress in Male Rat 1 2
Effects of Aging on LH and Prolactin after LHRH L-Dopa, Methyl-Dopa, and Stress in Male Rat 1 2
复制标题
雄性大鼠 LHRH、左旋多巴、甲基多巴和应激后衰老对 LH 和催乳素的影响 1 2
DOI：
10.3181/00379727-151-39246
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发表时间：
1976
影响因子：
--
通讯作者：
J. Meites
中科院分区：
文献类型：
--
作者：
G. Riegle;J. Meites
在给予l-多巴、甲基多巴、LHRH或应激处理的年轻（4-6个月）和老年（22-30个月）雄性Long-Evans大鼠中测试了下丘脑-垂体对催乳素和LH分泌的控制。治疗前血清LH水平始终高于青年组比老年组。注射LHRH后血清LH的增加仅为老年男性的一半左右。虽然急性应激引起血清LH的迅速增加，在年轻的雄性大鼠，这种治疗是没有效果的老年组。甲基多巴治疗刺激血清催乳素分泌在年轻和老年大鼠。虽然左旋多巴治疗引起血清催乳素在两个年龄组的减少，敏感性，幅度和持续时间的减少是较小的老年大鼠。
Summary Hypothalamic-pituitary control of prolactin and LH secretion was tested in young (4-6 months) and aged (22-30 months) male Long-Evans rats given l-dopa, methyl dopa, LHRH, or stress treatments. Pretreatment serum LH levels were consistently higher in young than in the aged groups. The increase in serum LH after LHRH injection was only about half as much in aged as compared to young control males. Although acute stress caused a prompt increase in serum LH in young male rats, this treatment was without effect in the aged group. Methyl dopa treatment stimulated serum prolactin secretion in both young and old rats. Although L-dopa treatment caused a reduction in serum prolactin in both age groups, the sensitivity, magnitude, and duration of the reduction was smaller in the aged rats.