Severe Involvement of Ambient Gyrus in Dementia with Grains
Severe Involvement of Ambient Gyrus in Dementia with Grains
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谷物对周围回的严重影响导致痴呆
DOI：
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发表时间：
2002
影响因子：
3.2
通讯作者：
S. Murayama
中科院分区：
文献类型：
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作者：
Yuko Saito;H. Yamanouchi;S. Murayama
嗜银颗粒在内侧颞叶的神经束中被检测到为点状或丝状结构，颗粒痴呆(DG)被定义为一种形式的痴呆，亲银颗粒是唯一可解释的原因。我们在社区老年医院的190例连续尸检的大脑中发现了43.2%的嗜银颗粒(平均年龄为79.7岁)，但这些嗜银颗粒阳性的大脑中只有20%符合DG的标准。为了确定认知正常的嗜银颗粒(CNG)和DG之间是否存在结构上的差异，我们研究了14个CNG和15个DG大脑。所有DG患者均有周围回(颞叶和杏仁核交界处)的严重萎缩，伴有海绵体、神经元丢失和胶质细胞增生，以及大量颗粒、椒盐、卷曲小体和tau免疫反应阳性的星形胶质细胞。CNG大脑的周围回没有类似的变化。与阿尔茨海默病相比，DG患者的颞叶新皮质和海马区相对较少。我们的研究表明，周围回的选择性严重受累可能解释了DG中边缘型痴呆的临床表现。
Argyrophilic grains are detected as punctate or filiform structures in the neuropil of the medial temporal lobe, and dementia with grains (DG) is defined as a form of dementia with argyrophilic grains as the only explainable cause. We found argyrophilic grains in 43.2% of our 190 serial autopsy brains (mean age, 79.7 yr) from a community-based geriatric hospital, but only 20% of these argyrophilic grain-positive brains fulfilled the criteria for DG. To determine if there are structural differences between cognitively normal cases with argyrophilic grains (CNG) and DG, we studied 14 brains with CNG and 15 brains with DG. All cases of DG had severe atrophy of the ambient gyrus (the junction between temporal lobe and amygdala) with spongiosis, neuronal loss, and gliosis, as well as many grains, pretangles, coiled bodies, and tau-immunoreactive astrocytes. Comparable changes were not present in the ambient gyrus of CNG brains. The temporal neocortex and hippocampus were relatively spared in DG, in contrast to Alzheimer disease. Our study suggests that selective severe involvement of the ambient gyrus may explain the clinical manifestations of a limbic-type dementia in DG.
晚发性痴呆伴有嗜银颗粒和皮质下缠结或非典型进行性核上性麻痹？
影响因子：
11.2
作者：
Masliah,E;Hansen,LA;Quijada,S;DeTeresa,R;Alford,M;Kauss,J;Terry,R
通讯作者：
Terry,R
影响因子：
--
作者：
J. C. Morris;R. Mohs;H. Rogers;G. Fillenbaum;A. Heyman
通讯作者：
J. C. Morris;R. Mohs;H. Rogers;G. Fillenbaum;A. Heyman