Accuracies and inaccuracies of the family history method: A multivariate approach
Accuracies and inaccuracies of the family history method: A multivariate approach
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DOI：
10.1111/j.1600-0447.1996.tb10639.x
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发表时间：
1996-04-01
影响因子：
6.7
通讯作者：
Kendler, KS
中科院分区：
文献类型：
--
作者：
Roy, MA;Walsh, D;Kendler, KS
本文报告了1459例精神分裂症或情感性疾病先证者的一级亲属和匹配的社区对照。我们试图（i）验证通过家族史（FH）获得的精神病诊断与通过基于个人访谈的最佳估计（BE）程序获得的精神病诊断，以及（ii）探索影响FH报告准确性的因素。我们发现FH和BE诊断之间的一致性相对较差，并且分歧受到许多因素的影响，包括性别、告密者的精神状态或先证者的诊断。当针对BE诊断进行验证时，FH方法的总体准确性相对较差，并且还受到若干偏差的影响。因此，用FH方法代替BE诊断可能是精神疾病家族/遗传因素调查中错误的一个重要来源。
This paper reports on 1459 first-degree relatives of probands with schizophrenia or affective illness and matched community controls. We sought (i) to validate psychiatric diagnoses obtained by family history (FH) against those obtained by a best estimate (BE) procedure based on personal interview and (ii) to explore the factors influencing the accuracy of the FH report. We found relatively poor agreement between the FH and BE diagnoses, and the disagreements were influenced by numerous factors, including gender, psychiatric status of the informant or proband's diagnosis. When validated against a BE diagnosis, the overall accuracy of the FH method is relatively poor, and is furthermore subject to several biases. Therefore, substituting the FH method for BE diagnosis may be an important source of error in the investigation of familial/genetic factors in psychiatric disorders.