Small open reading frames pack a big punch in cardiac calcium regulation.
Small open reading frames pack a big punch in cardiac calcium regulation.
复制标题
DOI：
10.1161/circresaha.113.302716
复制
发表时间：
2014-01-03
影响因子：
20.1
通讯作者：
Olson EN
中科院分区：
文献类型：
--
作者：
Nelson BR;Anderson DM;Olson EN
心脏收缩需要肌浆和肌浆网之间钙释放和再摄取的连续循环。在脊椎动物心肌细胞中，钙重新封存至肌浆网是由 SERCA 完成的，SERCA 的活性因与小的整合膜蛋白、受磷蛋白和肌磷脂的相互作用而减弱。在最近发表在《科学》杂志上的一份报告中，Magny 等人在果蝇中鉴定了一种假定的长非编码 RNA 中编码的 2 个小肽，该长非编码 RNA 可以缓冲肌/内质网 Ca2+-ATPase 2a 的钙再摄取，其方式与受磷蛋白和肌磷脂调节肌/内质网 Ca2+-ATPase 2a 的方式类似。这些发现表明，小跨膜肽对 Ca2+-ATP 酶的调节是一种保守且古老的策略。此外，这项研究强调了一种可能性，即在调节重要生物途径的假定的长非编码RNA中可能编码有许多未被发现的小肽。
Cardiac contraction requires continuous cycles of calcium release and reuptake between the sarcoplasm and sarcoplasmic reticulum. In vertebrate cardiomyocytes, re-sequestration of calcium to the sarcoplasmic reticulum is accomplished by the SERCA whose activity is dampened by interaction with the small integral membrane proteins, phospholamban and sarcolipin. In a recent report published in Science, Magny et al identify 2 small peptides in Drosophila encoded in a putative long noncoding RNA that buffers calcium reuptake by sarco/endoplasmic reticulum Ca2+-ATPase 2a in a similar manner to sarco/endoplasmic reticulum Ca2+-ATPase 2a regulation by phospholamban and sarcolipin. These findings demonstrate that regulation of Ca2+-ATPases by small transmembrane peptides is a conserved and ancient strategy. Furthermore, this study highlights the possibility that there may be many undiscovered small peptides encoded within putative long non-coding RNAs that regulate important biological pathways.