Extracellular matrix-mediated cellular communication in the heart.
Extracellular matrix-mediated cellular communication in the heart.
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DOI：
10.1016/j.yjmcc.2016.01.011
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发表时间：
2016-02
影响因子：
5
通讯作者：
Blaxall BC
中科院分区：
文献类型：
--
作者：
Valiente-Alandi I;Schafer AE;Blaxall BC
细胞外基质(ECM)是一种复杂的、动态的支架，维持组织的结构和动力学。然而，ECM作为一种惰性的架构支持的观点受到了越来越多的挑战。细胞外基质是一个充满活力的网络，是细胞微环境的重要组织者。它通过细胞和非细胞组织成分之间的复杂关系，在细胞相互作用中发挥直接作用，调节细胞的生长、存活、扩散、增殖、分化和迁移。这种复杂的相互关系在动态平衡期间保护心脏功能，但也是心肌损伤后的病理重塑的原因。因此，加强我们对这种串扰的理解可能会为心力衰竭的发病机制提供机械性的见解，并为新的、有针对性的药物治疗提供新的方法。本综述旨在探讨细胞外基质-细胞间相互作用在心肌损伤前和损伤后心肌细胞行为和心功能中的意义。
The extracellular matrix (ECM) is a complex and dynamic scaffold that maintains tissue structure and dynamics. However, the view of the ECM as an inert architectural support has been increasingly challenged. The ECM is a vibrant meshwork, a crucial organizer of cellular microenvironments. It plays a direct role in cellular interactions regulating cell growth, survival, spreading, proliferation, differentiation and migration through the intricate relationship among cellular and acellular tissue components. This complex interrelationship preserves cardiac function during homeostasis; however it is also responsible for pathologic remodeling following myocardial injury. Therefore, enhancing our understanding of this cross-talk may provide mechanistic insights into the pathogenesis of heart failure and suggest new approaches to novel, targeted pharmacologic therapies. This review explores the implications of ECM-cell interactions in myocardial cell behavior and cardiac function at baseline and following myocardial injury.