The importance of iron deficiency in pregnancy on fetal, neonatal, and infant neurodevelopmental outcomes.
The importance of iron deficiency in pregnancy on fetal, neonatal, and infant neurodevelopmental outcomes.
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DOI：
10.1002/ijgo.14951
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发表时间：
2023-08
期刊：
影响因子：
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通讯作者：
Michael K. Georgieff
中科院分区：
文献类型：
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作者：
Michael K. Georgieff
铁在神经发育中的作用早已被认识到，早期缺铁对大脑发育和随后的终生功能的不利影响继续是研究的主题。在过去的十年里，人们对母亲孕前铁状态和胎儿铁积累对后代、出生后铁状态和大脑健康的贡献有了更大的认识。这种思维模式的转变将之前相对孤立的两篇文献联系在一起：新生儿缺铁和出生后缺铁。了解到胎儿时期铁的积累强烈影响出生后的铁平衡，使人们认识到确保适当的胎儿铁负荷的重要性和价值。本文综述了胎儿铁代谢的动态，铁在胎儿大脑发育中的作用，胎儿铁负荷不足的短期和长期神经行为后果，以及胎儿/新生儿缺铁的潜在机制。
The role of iron in neurodevelopment has long been recognized, and the adverse effects of early-life iron deficiency on brain development and subsequent function across the lifespan continue to be a subject of research. A greater appreciation of the contribution of maternal preconceptional iron status and fetal iron accretion to offspring, postnatal iron status, and brain health across the lifespan has occurred over the past decade. This paradigm shift in thinking links two previously relatively siloed literatures: neonatal iron deficiency and postnatal iron deficiency. The understanding that iron accretion during the fetal period strongly influences postnatal iron balance has led to an appreciation of the importance and value of ensuring proper fetal iron loading. This article reviews the dynamics of fetal iron metabolism, the role of iron in the developing fetal brain, the short- and long-term neurobehavioral consequences of fetal iron underloading, and the potential mechanisms that account for the long-term effects of fetal/neonatal iron deficiency.