Investigation of Acinetobacter baumannii resistance to carbapenems in Marseille hospitals, south of France: a transition from an epidemic to an endemic situation
Investigation of Acinetobacter baumannii resistance to carbapenems in Marseille hospitals, south of France: a transition from an epidemic to an endemic situation
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DOI：
10.1111/j.1600-0463.2012.02935.x
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发表时间：
2013-01-01
期刊：
影响因子：
2.8
通讯作者：
Raoult, Didier
中科院分区：
文献类型：
--
作者：
Kempf, Marie;Rolain, Jean-Marc;Raoult, Didier
[10]杨文辉，李文辉.法国南部马赛医院鲍曼不动杆菌对碳青霉烯类抗生素耐药性的调查：从流行病到地方病的转变APMIS 2013; 121：64-71.碳青霉烯类耐药鲍曼不动杆菌感染是一种世界范围的地方性医院内威胁。2010年12月至2011年4月，耐碳青霉烯类A.鲍曼不动杆菌感染发生在几所马赛大学医院。本研究的目的是调查碳青霉烯类耐药A。鲍曼不动杆菌感染，并表征碳青霉烯耐药的机制。这种增加是由一个名为EPIMIC的自制计算机监测程序检测到的，该程序每周监测抗生素耐药性概况。在此期间，耐碳青霉烯类A。鲍曼不动杆菌来自不同单位的住院患者。采用脉冲场凝胶电泳（PFGE）和多位点序列分型（MLST）对分离株进行基因分型，并进行碳青霉烯酶基因分析，以检测是否存在碳青霉烯酶，并确定分离株之间的关系。抗碳青霉烯A.共十一名病人在不同的医院单位接受鲍曼不动杆菌隔离。我们在所有分离株中鉴定了bla（OXA 23样）碳青霉烯酶编码基因的存在，并发现了4个主要PFGE组和不同的MLST组。这些结果表明，目前的演变，在A。马赛鲍曼不动杆菌流行病学研究，从流行病转变为地方病，并有几个循环克隆。
Kempf M, Rolain J-M, Azza S, Diene S, Joly-Guillou M-L, Dubourg G, Colson P, Papazian L, Richet H, Fournier P-E, Ribeiro A, Raoult D. Investigation of Acinetobacter baumannii resistance to carbapenems in Marseille hospitals, south of France: a transition from an epidemic to an endemic situation. APMIS 2013; 121: 64-71.Carbapenem-resistant Acinetobacter baumannii infections are a worldwide endemic nosocomial threat. Between December 2010 and April 2011, an increase of carbapenem-resistant A. baumannii infections occurred in several Marseille University Hospitals. The aim of this study was to investigate the increase of carbapenem-resistant A. baumannii infections and to characterize the mechanisms of carbapenem resistance. The increase was detected by a homemade computer surveillance program, known as EPIMIC, that monitors antibiotic resistance profiles on a weekly basis. During this period, positive samples of carbapenem-resistant A. baumannii were retrieved from patients hospitalized in different units. Genotyping of the isolates was performed using pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST), and carbapenemase gene analyses were performed to detect the presence of carbapenemases and to determine the relationships of the isolates. Carbapenem-resistant A. baumannii were isolated in a total of 11 patients who were hospitalized in different hospitals units. We identified the presence of the bla(OXA23-like) carbapenemase-encoding gene in all of the isolates and found four major PFGE groups and different MLST groups. These results demonstrate a current evolution in the A. baumannii epidemiology in Marseille with a switch from an epidemic situation to an endemic situation and with several circulating clones.