SIGMA-1 RECEPTORS MODULATE FUNCTIONAL-ACTIVITY OF RAT SPLENOCYTES
SIGMA-1 RECEPTORS MODULATE FUNCTIONAL-ACTIVITY OF RAT SPLENOCYTES
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DOI：
10.1016/0165-5728(95)00032-w
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发表时间：
1995-06-01
影响因子：
3.3
通讯作者：
WOLFE, SA
中科院分区：
文献类型：
--
作者：
LIU, YH;WHITLOCK, BB;WOLFE, SA
抗精神病药、阿片类药物和可卡因通常被人类处方或滥用。虽然主要用于其在大脑中的其他受体的作用，但这些化合物也作用于σ受体。我们以前已经确定了人外周血白细胞和大鼠脾脏上的sigma-1受体，在本研究中，我们证明了这些受体的药理学和药物抑制伴刀豆球蛋白A诱导的脾细胞增殖的能力之间的相关性。这些结果支持了σ-1受体调节免疫细胞功能活性的假设，并表明σ激动剂可引起体内免疫能力的变化。
Neuroleptics, opiates, and cocaine are commonly prescribed for or abused by humans. Although primarily used for their actions at other receptors in brain, these compounds also act at sigma receptors. We have previously identified sigma-1 receptors on human peripheral blood leukocytes and rat spleen, and in the present study we demonstrate a correlation between the pharmacology of these receptors and the ability of drugs to suppress concanavalin A-induced splenocyte proliferation. These results support the hypothesis that sigma-1 receptors regulate functional activities of immune cells, and suggest that sigma agonists may cause changes in immune competence in vivo.