Spinal Transection Switches the Effect of Metabotropic Glutamate Receptor Subtype 7 from the Facilitation to Inhibition of Ejaculation
Spinal Transection Switches the Effect of Metabotropic Glutamate Receptor Subtype 7 from the Facilitation to Inhibition of Ejaculation
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脊髓横断将代谢型谷氨酸受体亚型 7 的作用从促进射精转变为抑制射精
DOI：
10.1016/j.neuroscience.2022.11.012
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发表时间：
2023
期刊：
影响因子：
3.3
通讯作者：
Kawauchi Akihiro
中科院分区：
文献类型：
--
作者：
Masugi-Tokita Miwako;Kubota Shigehisa;Kobayashi Kenichi;Yoshida Tetsuya;Kageyama Susumu;Sakamoto Hirotaka;Kawauchi Akihiro
代谢型谷氨酸受体亚型7（mGluR7）是III组mGluR的成员，其定位于中枢神经系统的突触前活性区。我们以前报道过mGluR7基因敲除（KO）小鼠表现出射精障碍，尽管它们有正常的性动机。我们假设mGluR7通过增强腰骶脊髓神经回路的兴奋性来调节射精，因为给该区域注射mGluR7选择性拮抗剂可以抑制药物诱导的射精。在本研究中，为了阐明mGluR7基因敲除小鼠射精障碍的机制，我们通过脊髓横断（spinalization）消除了大脑的影响。出乎意料的是，雄性mGluR7基因敲除小鼠的性反应比野生型小鼠在脊髓化后的性反应更强。组织学检查表明，mGluR7控制交感神经元以及副交感神经元。鉴于其突触调控的复杂性，mGluR7可能通过多层次、多方式调控射精。我们的研究提供了对射精机制的深入了解，以及未来治疗人类射精障碍的策略。
Metabotropic glutamate receptor subtype 7 (mGluR7) is a member of the group III mGluRs, which localize to presynaptic active zones of the central nervous system. We previously reported that mGluR7 knockout (KO) mice exhibit ejaculatory disorders, although they have normal sexual motivation. We hypothesized that mGluR7 regulates ejaculation by potentiating the excitability of the neural circuit in the lumbosacral spinal cord, because administration of the mGluR7-selective antagonist into that region inhibits drug-induced ejaculation. In the present study, to elucidate the mechanism of impaired ejaculation in mGluR7 KO mice, we eliminated the influence of the brain by spinal transection (spinalization). Unexpectedly, sexual responses of male mGluR7 KO mice were stronger than those of wild-type mice after spinalization. Histological examination indicated that mGluR7 controls sympathetic neurons as well as parasympathetic neurons. In view of the complexity of its synaptic regulation, mGluR7 might control ejaculation by multi-level and multi-modal mechanisms. Our study provides insight into the mechanism of ejaculation as well as a strategy for future therapies to treat ejaculatory disorders in humans.
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α-肾上腺素能受体分类的功能基础
DOI：
--
发表时间：
1977
期刊：
影响因子：
--
作者：
S. Berthelsen;W. Pettinger
通讯作者：
W. Pettinger
α-肾上腺素受体调节雄性大鼠性行为的证据
DOI：
--
发表时间：
1985
期刊：
影响因子：
--
作者：
John T. Clark;Erla R. Smith;J. Davidson
通讯作者：
J. Davidson
脊髓雄性家鼠的性反射
影响因子：
2.9
作者：
Benjamin D. Sachs
通讯作者：
Benjamin D. Sachs
代谢型谷氨酸受体亚型 7 消融导致恐惧反应和条件性味觉厌恶缺陷
影响因子：
5.3
作者：
M. Masugi;M. Yokoi;R. Shigemoto;K. Muguruma;Yasuyoshi Watanabe;G. Sansig;H. van der Putten;S. Nakanishi
通讯作者：
S. Nakanishi
代谢型谷氨酸受体亚型 7 对于射精至关重要
影响因子：
5.1
作者：
Masugi-Tokita Miwako;Tomita Keiji;Kobayashi Kenichi;Yoshida Tetsuya;Kageyama Susumu;Sakamoto Hirotaka;Kawauchi Akihiro
通讯作者：
Kawauchi Akihiro