RELATIONSHIPS OF HIPPOCAMPAL THETA CYCLES WITH BAR PRESSING DURING SELF-STIMULATION
RELATIONSHIPS OF HIPPOCAMPAL THETA CYCLES WITH BAR PRESSING DURING SELF-STIMULATION
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DOI：
10.1016/0031-9384(77)90035-x
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发表时间：
1977-01-01
影响因子：
2.9
通讯作者：
VELLUTI, JC
中科院分区：
文献类型：
--
作者：
BUNO, W;VELLUTI, JC
先前的报道证明了海马节律性慢活动（θ）和运动，并表明有节奏的运动往往发生在θ的某个阶段。之间的关系。自行车和自愿的运动活动进行了调查。脑电刺激的压棒法为海马活动的相关性提供了参考。进行中. θ按压前后振幅和频率增加。周期性的波在按压之前和之后。这些波仅在按压发生在θ的特定相位时出现。自行车.在持续4-8 h的疗程中，它们逐渐消失。添加到杠杆上的轻重量（< 90 g）不改变θ，但较重的重量（> 90 g）产生的平均值没有周期波，但具有运动相关电位。介绍了按和电刺激延迟诱发电位之间的延迟，而平均表示，周期性波持续之前和之后的酒吧按。间隔或上级穹窿的全部病变消除了θ。增加了自我刺激的频率。在具有部分损伤的动物中，θ在按压过程中再次出现。由于大鼠倾向于在θ的特定阶段进行杠杆按压，相位锁定的θ可能是运动机制的必然结果，也可能是运动反应的时间。
Previous reports demonstrated a relationship between hippocampal rhythmical slow activity (.theta.) and movement, and suggested that rhythmical movements tend to occur during certain phase of .theta.. The relationships between .theta. cycles and voluntary motor activity were investigated. Bar pressing for electrical brain stimulation provided the reference to relate hippocampal activity. Ongoing .theta. increased in amplitude and frequency before and after pressing. Periodic waves preceded and followed pressing. These waves only appeared if the presses occurred at particular phases of the .theta. cycles. They gradually disappeared during sessions lasting 4-8 h. Light weights (< 90 g) added to the lever did not alter .theta., but heavier weights (> 90 g) produced averages without periodic waves and with movement-related potentials. Introduction of a delay between pressing and electrical stimulation delayed evoked potentials, while averaging indicated that periodical waves persisted before and after bar pressing. Total lesions of the septum or superior fornix abolished .theta. and increased the frequency of self stimulation. In animals with partial lesions, .theta. reappeared during pressing. Since the rats tended to lever press during particular phases of .theta., the phase-locked .theta. may be a corollary of motor mechanisms, and perhaps of the timing of motor responses.