Fruitless and doublesex coordinate to generate male-specific neurons that can initiate courtship
Fruitless and doublesex coordinate to generate male-specific neurons that can initiate courtship
复制标题
DOI：
10.1016/j.neuron.2008.06.007
复制
发表时间：
2008-09-11
期刊：
影响因子：
16.2
通讯作者：
Yamamoto, Daisuke
中科院分区：
文献类型：
--
作者：
Kimura, Ken-ichi;Hachiya, Tomoaki;Yamamoto, Daisuke
生物学家假设，大脑中的性别差异是行为性别差异的基础，但对此的直接证据一直很少。我们在果蝇中发现了一个雄性特异的、无果(FRU)/双性(DsX)共表达的神经元簇P1。即使在大脑的其他部分没有男性化的情况下，在女性身上人工诱导P1克隆也有效地激发了这种女性的男性典型行为。P1位于蘑菇体附近的背侧后脑，由20个中间神经元组成，每个中间神经元都有一个初级横突，在双侧前脑内有广泛的分支。P1注定要通过女性化蛋白DsxF的作用在雌性体内死亡。男性大脑中需要一种男性化蛋白Fru，以正确定位P1突起的终末。因此，两个性别决定基因dsx和fru的协同作用赋予了在P1神经元上启动典型男性性行为的独特能力。
Biologists postulate that sexual dimorphism in the brain underlies gender differences in behavior, yet direct evidence for this has been sparse. We identified a male-specific, fruitless (fru)/doublesex (dsx)-coexpressing neuronal cluster, P1, in Drosophila. The artificial induction of a P1 clone in females effectively provokes male-typical behavior in such females even when the other parts of the brain are not masculinized. P1, located in the dorsal posterior brain near the mushroom body, is composed of 20 interneurons, each of which has a primary transversal neurite with extensive ramifications in the bilateral protocerebrum. P1 is fated to die in females through the action of a feminizing protein, DsxF. A masculinizing protein Fru is required in the male brain for correct positioning of the terminals of P1 neurites. Thus, the coordinated actions of two sex determination genes, dsx and fru, confer the unique ability to initiate male-typical sexual behavior on P1 neurons.