Investigation of bone changes in microgravity during long and short duration space flight: comparison of techniques
Investigation of bone changes in microgravity during long and short duration space flight: comparison of techniques
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DOI：
10.1046/j.1365-2362.2000.00719.x
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发表时间：
2000-12-01
影响因子：
5.5
通讯作者：
Vahlensieck, M
中科院分区：
文献类型：
--
作者：
McCarthy, I;Goodship, A;Vahlensieck, M
背景骨质流失是长期太空飞行中持续存在的问题。虽然反措施方案已经制定，这些方案的有效评估是阻碍了缺乏监测技术，可以使用inflight.Materials和方法-三种技术被用来评估骨的变化，在两个任务的180和20天的和平号空间站，涉及三个主题。在飞行前后使用双能X线吸收法（DXA）测量全身和局部骨密度（BMD）。在180天使命期间和20天使命前后测量跟骨超声速度（SOS）和宽带衰减（BUA）。在胫骨弯曲波的相位速度也测量了超声measurements of the calcaneus.Results的DXA测量显示在身体的不同部位之间的BMD的变化，最大的变化发生在腰椎和股骨近端的显着变化的同一天。在180使命期间，胫骨中的相速度有增加的趋势，但这并不显著。跟骨BUA和SOS测量结果一致，但不同的变化模式在使命。结论虽然在飞行中使用超声或相速度测量骨可能提供的信息，在太空飞行中的骨丢失的动力学，在骨骼的异质性的反应意味着，它是很难预测的整体骨丢失从测量在一个特定的网站。
Background Loss of bone mass is a continuing problem in long-term space flight. Although counter-measure programmes have been developed, effective assessment of these programmes is hampered by a lack of monitoring techniques that can be used in-flight.Materials and methods Three techniques were used to evaluate changes in bone during two missions of 180 and 20 days to the MIR space station, involving three subjects. Dual energy X-ray absorptiometry (DXA) was used before and after flight to measure whole body and regional bone mineral density (BMD). Ultrasonic measurements of velocity (SOS) and broadband attenuation (BUA) of the calcaneus were measured during the 180 day mission and before and after the 20 day mission. Phase velocity of flexural waves in the tibia was also measured on the same days as the ultrasonic measurements of the calcaneus.Results DXA measurements demonstrated significant variation between different sites in the body for changes in BMD, with the greatest changes occurring in the lumbar spine and proximal femur. There was a trend for increasing phase velocity in the tibia during the 180 mission, but this was not significant. BUA and SOS measurements of the calcaneus showed consistent but divergent patterns of changes during the mission.Conclusion Although in-flight measurements of bone using ultrasound or phase velocity may provide information on the kinetics of bone loss in space flight, the heterogeneity of response in the skeleton means that it is difficult to predict overall bone loss from measurements at one particular site.