Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids.
Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids.
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DOI：
10.1002/hipo.20947
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发表时间：
2012-04
期刊：
影响因子：
3.5
通讯作者：
Gould E
中科院分区：
文献类型：
--
作者：
Leuner B;Caponiti JM;Gould E
催产素与社会行为有关，包括社会认可、伴侣关系和养育子女，但其在促进神经元生长方面的潜在作用尚未得到研究。我们在这里表明，催产素（而不是加压素）刺激大鼠海马中的细胞增殖和成体神经发生。催产素还能够刺激接受糖皮质激素给药或冷水游泳应激的大鼠的成年神经发生。这些发现表明，催产素可以刺激神经元生长，并可以防止应激激素对海马可塑性的抑制作用。
Oxytocin has been linked to social behavior, including social recognition, pair bonding and parenting, but its potential role in promoting neuronal growth has not been investigated. We show here that oxytocin, but not vasopressin, stimulates both cell proliferation and adult neurogenesis in the hippocampus of rats. Oxytocin is also capable of stimulating adult neurogenesis in rats subjected to glucocorticoid administration or cold water swim stress. These findings suggest that oxytocin stimulates neuronal growth and may protect against the suppressive effects of stress hormones on hippocampal plasticity.